Author

A. L. Graham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Ecology· 5 Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 5 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

K. Cadwell· 3 shared P. Loke· 3 shared A. Cronkite· 2 shared A. E. Downie· 2 shared C. B. Hansen· 2 shared C. Drake-Dunn· 2 shared C. Hansen· 2 shared C. McCauley· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

K. Cadwell

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Author profile →

8 papers

Recent·Most cited

Dose-dependent interaction of parasites with tiers of host defence generates "wormholes" that prolong infection at intermediate inoculum sizes

A. L. Graham, R. R. Regoes

The paper models how parasite doses interact with host defense tiers, finding that intermediate doses prolong infections by partially overcoming defenses without triggering strong adaptive responses.

bioRxiv · Jun 9, 2023 · PreprintEcology

Social association predicts immunological similarity in rewilded mice

A. E. Downie, O. Oyesola, R. S. Barre, Q. Caudron, Y.- H. Chen, E. J. Dennis, R. Garnier, K. Kiwanuka, A. Menezes, D. J. Navarrete, O. Mondragon-Palomino, J. B. Saunders, C. K. Tokita, K. Zaldana, K. Cadwell, , A. L. Graham

The paper shows that social association in rewilded mice predicts immunological similarity, with social ties more influential than genetic or parasitic factors.

bioRxiv · Mar 15, 2023 · PreprintImmunology

Natural strongyle infection reduces relative abundance of inflammation-inducing Prevotella in wild primates

C. A. Cizauskas, A. D. Washburne, J. E. Knelman, C. B. Hansen, A. M. Nderitu, P. L. Esinyon, A. Dobson, A. L. Graham

The paper investigates the relationship between natural strongyle infection and changes in the gut microbiome of wild primates, finding reduced Prevotella abundance linked to inflammation.

bioRxiv · Jun 2, 2022 · PreprintEcology

Optimal immune specificity at the intersection of host life history and parasite epidemiology

A. E. Downie, A. Mayer, C. J. E. Metcalf, A. L. Graham

This study examines how life history and epidemiology interact to shape optimal immune strategy using a demographic model of parasite recognition and response.

bioRxiv · Mar 11, 2021Ecology

Experimental parasite community perturbation reveals associations between Sin Nombre virus and gastrointestinal nematodes in a rodent reservoir host

A. R. Sweeny, C. A. Thomason, E. A. Carbajal, C. B. Hansen, A. L. Graham, A. B. Pedersen

The paper experimentally perturbs parasite communities in rodent hosts to show that reducing nematode infection increases Sin Nombre virus seroprevalence and improves survival in co-infected mice.

bioRxiv · Aug 16, 2020Ecology

Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence

C. E. Brook, M. Boots, K. Chandran, A. P. Dobson, C. Drosten, A. L. Graham, B. Grenfell, M. A. Müller, M. Ng, L.-F. Wang, A. van Leeuwen

The paper models viral dynamics in bat cell lines with constitutive immune responses, finding that robust antiviral defenses correlate with higher viral propagation rates and suggest implications for zoonotic emergence.

bioRxiv · Feb 1, 2020Ecology

Housing laboratory mice deficient for Nod2 and Atg16l1 in a natural environment uncovers genetic and environmental contributions to immune variation.

J.-D. Lin, J. C. Devlin, F. Yeung, C. McCauley, J. M. Leung, Y.-H. Chen, A. Cronkite, C. Hansen, C. Drake-Dunn, K. V. Ruggles, K. Cadwell, A. L. Graham, P. Loke

Exposing mice with genetic mutations to a natural environment reveals environmental effects on immune cell populations and genetic effects on cytokine responses.

bioRxiv · Dec 9, 2019Immunology

Altered immunity of laboratory mice in the natural environment is associated with fungal colonization

F. Yeung, Y.-H. Chen, J.-D. Lin, J. M. Leung, C. McCauley, J. C. Devlin, C. Hansen, A. Cronkite, Z. W. Stephens, C. Drake-Dunn, K. V. Ruggles, J. L. Round, P. Loke, A. L. Graham, K. Cadwell

This study shows that rewilding laboratory mice in an outdoor environment alters their immune system, increasing granulocytes and changing microbiota, but not causing infection from known pathogens.

bioRxiv · Dec 9, 2019Immunology