Y.-H. Chen

Branch-Wise Regularization for Heterogeneous GNN-Based MALDI-TOF AMR Prediction with Biomarker-Consensus Edges

This paper evaluates a heterogeneous GNN for AMR prediction from MALDI-TOF spectra, showing it performs better than MLP only at high spectral similarity.

Enabling Systemic Identification and Functionality Profiling for Cdc42 Homeostatic Modulators

This study systematically identifies and classifies Cdc42 homeostatic modulators using a combination of experimental profiling and computer-aided drug discovery, revealing five functionally distinct classes with potential therapeutic applications.

Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases

This study shows that autologous NK cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases in a mouse model and a clinical trial.

Fast exploration is coupled with a less choosy but more reactive learning style in a generalist predator

This study examines the relationship between exploration speed and learning style in sun skinks, finding fast explorers are less choosy but more reactive foragers, contradicting conventional predictions.

A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular Lesions

This paper develops a microphysiological HHT-on-a-chip platform that recapitulates patient vascular lesions and demonstrates sensitivity to pazopanib, a drug effective in HHT patients.

Xylosyltransferase Bump-and-hole Engineering to Chemically Manipulate Proteoglycans in Mammalian Cells

This paper develops a chemical genetic strategy to manipulate proteoglycan glycan attachment sites in mammalian cells using modified xylosyltransferases.

Perturbation of tonoplast sucrose transport alters carbohydrate utilization for seasonalgrowth and defense metabolism in coppiced poplar

This study shows that SUT4 modulates seasonal trade-offs between growth and defense metabolism in poplar by affecting carbohydrate utilization during coppicing.

Genetic and Environmental interactions contribute to immune variation in rewilded mice

This study examines how genetics and environment interact to influence immune variation in rewilded mice, finding that genotype drives cytokine responses while genotype-environment interactions shape cellular composition.

Titering of Chimeric Antigen Receptors on CAR T Cells enabled by a Microfluidic-based Dosage-Controlled Intracellular mRNA Delivery Platform

This paper introduces a microfluidic platform for controlled delivery of CAR gene mRNA to T cells, enabling titering of CAR expression on their surface.

3D Confinement-enabled Priming of Synaptic Activation Promotes Primary T Cell Expansion

This paper introduces a 3D confinement method to prime T cell-MHC immune synapses, achieving faster T cell expansion compared to conventional methods.

Short Tandem Repeat Profiling via Next Generation Sequencing for Cell Line Authentication

This study compares NGS-based STR profiling with traditional STR-CE for cell line authentication, finding NGS offers better sequence context, sensitivity, and multiplexing.

Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA polyubiquitination

Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization

The paper shows that overproduction of REG3 proteins in IBD flares reduces Enterococcus faecium, worsening inflammation by disrupting microbiota-immune interactions.

Indole produced during dysbiosis mediates host-microorganism chemical

The paper shows that indole, produced by E. coli during gut dysbiosis in C. elegans, activates DAF-16 to enhance host fitness by limiting bacterial accumulation.

Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection

The paper uses a glycoengineered keratinocyte library to identify specific glycans essential for different stages of HSV-1 infection.

Multiplex editing of the Nucleoredoxin1 tandem array in poplar: from small indels to translocations and complex inversions

This study uses CRISPR-Cas9 to edit a tandem array of seven NRX1 genes in poplar, generating diverse mutations including indels, deletions, translocations, and inversions.

EZH2/ hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression

This study identifies the EZH2/SULF1/cMET axis as a driver of chondrosarcoma progression and shows that targeting this pathway can slow tumor growth and improve survival in mouse models.

A wheat resistosome defines common principles of immune receptor channels

This study reports the cryo-EM structure of the wheat CNL Sr35 resistosome and shows its structural and functional conservation with the Arabidopsis ZAR1 resistosome.

Molecular basis for the R-type anion channel QUAC1 activity in guard cells

This study determines the cryo-EM structure of QUAC1, an R-type anion channel, revealing its dimeric architecture and mechanism of malate-mediated activation.

Variable susceptibility of intestinal organoid-derived monolayers to SARS-CoV-2 infection

This study examines inter-individual variability in SARS-CoV-2 infection of intestinal organoids, finding that ACE2 expression levels determine susceptibility and that Omicron variant shows higher infectivity.

Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition

This study shows that low-dose antibiotic residue exposure in early life alters gut microbiota and bile acid composition, leading to long-term metabolic disorders in mice.

Sequencing uracil in DNA at single-nucleotide resolution

This paper introduces SNU-seq, a method for single-nucleotide uracil mapping in DNA, validated on synthetic DNA and mammalian genomes, revealing uracil dynamics in treated cells and AID hotspots.

Hot water extract of Arthrospira maxima (AHWE) has broad-spectrum antiviral activity against RNA virus including coronavirus SARS-CoV2, and the antivirus spray application

This study demonstrates that AHWE from Arthrospira maxima inhibits multiple RNA viruses, including SARS-CoV2, with no toxicity, suggesting its potential as a broad-spectrum antiviral spray.

Impact of glycosylation on a broad-spectrum vaccine against SARS-CoV-2

This study shows that trimming N-glycans from the SARS-CoV-2 spike protein enhances immune responses and protection against variants in hACE2 mice.

Complete and high-quality genomes of novel microbial species from a meromictic lake using a workflow combining long- and short-read sequencing platforms

This paper develops a workflow combining long- and short-read sequencing to reconstruct high-quality MAGs from a meromictic lake, recovering 154 novel species and demonstrating the method's effectiveness in genome-centric metagenomics.

A genomic view of coral-associated Prosthecochloris and a companion sulfate-reducing bacterium

This study identifies and characterizes novel genomes of coral-associated Prosthecochloris and a sulfate-reducing bacterium, revealing their genomic and metabolic traits and a potential syntrophic relationship in coral endolithic communities.

High-throughput and dosage-controlled intracellular delivery of large cargos by an acoustic-electric micro-vortices platform

The paper introduces a microfluidic platform for high-throughput, dosage-controlled intracellular delivery of large cargos with high viability and efficiency.

Prevalence, complete genome and metabolic potentials of a phylogenetically novel cyanobacterial symbiont in the coral-killing sponge, Terpios hoshinota

The paper identifies a novel cyanobacterial symbiont in the coral-killing sponge Terpios hoshinota, characterizes its genome and metabolic potential, and proposes a new genus and species.

The hyperlipidaemic drug fenofibrate significantly reduces infection by SARS-CoV-2 in cell culture models

This study shows fenofibrate and its metabolite fenofibric acid reduce SARS-CoV-2 infection in cell culture by up to 70% at clinically achievable concentrations.

CpG-adjuvanted stable prefusion SARS-CoV-2 spike protein protected hamsters from SARS-CoV-2 challenge

This study shows that CpG-adjuvanted S-2P vaccine protected hamsters from SARS-CoV-2 infection by inducing high neutralizing antibodies and reducing viral load.