P. Loke

Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness

This study uses patient-derived intestinal organoids to predict individual clinical responsiveness to tofacitinib in ulcerative colitis by assessing drug sensitivity and MATE1 expression.

A role for BCL6 in maintaining CX3CR1+ CD4+ T cells during helminth infection

The paper identifies BCL6's role in maintaining CX3CR1+ CD4+ T cells during helminth infections through fate-mapping and single-cell RNA-sequencing.

Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation

The paper characterizes functional properties of helminth-associated Clostridiales bacteria and identifies their role in promoting Treg differentiation and Trichuris egg hatching.

Genetic and Environmental interactions contribute to immune variation in rewilded mice

This study examines how genetics and environment interact to influence immune variation in rewilded mice, finding that genotype drives cytokine responses while genotype-environment interactions shape cellular composition.

Social association predicts immunological similarity in rewilded mice

The paper shows that social association in rewilded mice predicts immunological similarity, with social ties more influential than genetic or parasitic factors.

Single-cell analysis of CX3CR1+ cells reveal a pathogenic role for BIRC5+ myeloid proliferating cells driven by Staphylococcus aureus leukotoxins

The paper identifies BIRC5+ myeloid cells as pathogenic during S. aureus infection using scRNA-seq and genetic fate mapping.

Helminth exposure protects against murine SARS-CoV-2 infection through macrophage dependent T cell activation

This study shows that prior helminth infection reduces SARS-CoV-2 viral loads in mice by enhancing CD8+ T cell responses through macrophage-dependent mechanisms.

Clostridia isolated from helminth-colonized humans promote hatching of Trichuris muris

The paper isolates and characterizes Clostridia from helminth-colonized humans, showing they promote hatching of Trichuris muris eggs.

Gut Microbiome of Helminth Infected Indigenous Malaysians Is Context Dependent

The paper analyzes gut microbiomes of helminth-infected indigenous Malaysians, finding context-dependent effects of helminth infections and albendazole treatment on microbial diversity and composition.

The immune response and microbiota profiles during co-infection with P. vivax and soil-transmitted helminths

This study investigates the immune response and microbiota changes in individuals co-infected with P. vivax and soil-transmitted helminths, finding that P. vivax has a stronger association with microbiome alterations than STH.

Transcriptional Atlas of Ileal-Anal Pouch Immune Cells from Ulcerative Colitis Patients

The paper uses single-cell RNA-sequencing to analyze immune cells in ileal pouches and colons of UC patients, identifying specific cell types and their association with inflammation and treatment response.

The helminth glycoprotein omega-1 improves metabolic homeostasis in obese mice through type-2 immunity-independent inhibition of food intake

This paper shows that the helminth glycoprotein omega-1 improves metabolic health in obese mice by reducing food intake, independent of type 2 immunity.

Alternative activation of macrophages is accompanied by chromatin remodeling and short-term dampening of macrophage secondary response

The paper shows IL-4 activates macrophages with chromatin remodeling and dampens secondary responses, with genetic differences affecting outcomes.

Housing laboratory mice deficient for Nod2 and Atg16l1 in a natural environment uncovers genetic and environmental contributions to immune variation.

Exposing mice with genetic mutations to a natural environment reveals environmental effects on immune cell populations and genetic effects on cytokine responses.

Altered immunity of laboratory mice in the natural environment is associated with fungal colonization

This study shows that rewilding laboratory mice in an outdoor environment alters their immune system, increasing granulocytes and changing microbiota, but not causing infection from known pathogens.

Distinct features of human myeloid cell cytokine response profiles identify neutrophil activation by cytokines as a prognostic feature during tuberculosis and cancer

The paper identifies neutrophil cytokine response profiles as prognostic markers in tuberculosis and cancer by analyzing myeloid cell transcriptional responses to various cytokines.

Serum Amyloid A Proteins Induce Pathogenic TH17 Cells and Promote Inflammatory Disease

This study shows serum amyloid A proteins drive pathogenic TH17 cell differentiation and promote inflammatory disease through STAT3-activating cytokines.