Author

A. L. Lourenco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Bioengineering· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:protein design· 1

Frequent Co-Authors

C. S. Craik· 3 shared A. J. O'Donoghue· 2 shared A. A. da Silva· 1 shared A. E. Mayer Bridwell· 1 shared A. M. Klinger· 1 shared A. M. Subramanian· 1 shared A. Poso· 1 shared B. Woodworth· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

C. S. Craik

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Unexplored regions of the protein sequence-structure map revealed at scale by a library of foldtuned language models

A. M. Subramanian, Z. A. Martinez, A. L. Lourenco, S. C. Yuan, S. Liu, T.-Y. Wang, T.-F. Chou, M. Thomson

This paper introduces foldtuning, a method to generate novel protein sequences with target structures, bypassing evolutionary barriers and enabling synthetic biology applications.

bioRxiv · Dec 22, 2023 · PreprintBioengineering

Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors.

P. Rashmi, T. K. Sigdel, D. Rychkov, I. Damm, A. A. da Silva, F. Vincenti, A. L. Lourenco, C. S. Craik, J. Reiser, M. M. Sarwal

This paper investigates how circulating factors like suPAR and CD40 autoantibodies induce podocyte injury in FSGS and identifies therapeutic targets for rFSGS.

Annals of Translational Medicine · Jun 1, 2023Peer-reviewedImmunology

Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2

L. H. Santos, T. Kronenberger, R. G. Almeida, E. Barbosa da Silva, R. E. O. Rocha, J. C. Oliveira, L. V. Barreto, D. Skinner, P. Fajtova, M. A. Giardini, B. Woodworth, C. Bardine, A. L. Lourenco, C. S. Craik, A. Poso, , R. Ferreira

This study identifies naphthoquinone derivatives as inhibitors of SARS-CoV-2 proteases Mpro and PLpro through virtual screening and biochemical assays.

bioRxiv · Jan 5, 2022Biochemistry

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

M. Mahoney, V. C. Damalanka, M. Tartell, D. H. Chung, A. L. Lourenco, D. Pwee, A. E. Mayer Bridwell, M. Hoffmann, J. Voss, P. Karmakar, N. P. Azouz, A. M. Klinger, P. W. Rothlauf, C. E. Thompson, M. Lee, , J. W. Janetka

This paper identifies a novel class of TMPRSS2 inhibitors that effectively block SARS-CoV-2 and MERS-CoV entry and show promise as a therapeutic for COVID-19.

bioRxiv · May 6, 2021Microbiology