Author

C. Bardine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Organism:virus· 2 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

C. S. Craik· 3 shared A. J. O'Donoghue· 2 shared B. K. Shoichet· 2 shared P. Fajtova· 2 shared A. Garcia-Sastre· 1 shared A. L. Lourenco· 1 shared A. Poso· 1 shared A. R. Renslo· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

C. S. Craik

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors

E. A. Fink, C. Bardine, S. Gahbauer, I. Singh, K. White, S. Gu, X. Wan, B. Ary, I. Glenn, J. O'Connell, H. O'Donnell, P. Fajtova, J. Lyu, S. Vigneron, N. J. Young, , C. S. Craik

The paper identifies novel non-covalent and covalent inhibitors of SARS-CoV-2 main protease through virtual docking and experimental validation.

bioRxiv · Jul 5, 2022Biophysics

Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2

L. H. Santos, T. Kronenberger, R. G. Almeida, E. Barbosa da Silva, R. E. O. Rocha, J. C. Oliveira, L. V. Barreto, D. Skinner, P. Fajtova, M. A. Giardini, B. Woodworth, C. Bardine, A. L. Lourenco, C. S. Craik, A. Poso, , R. Ferreira

This study identifies naphthoquinone derivatives as inhibitors of SARS-CoV-2 proteases Mpro and PLpro through virtual screening and biochemical assays.

bioRxiv · Jan 5, 2022Biochemistry

Colloidal aggregators in biochemical SARS-CoV-2 repurposing screens

H. R. O'Donnell, T. A. Tummino, C. Bardine, C. S. Craik, B. K. Shoichet

This study identifies colloidal aggregators in SARS-CoV-2 drug repurposing screens, showing that many drugs form colloids at therapeutic concentrations, potentially leading to false positive results.

bioRxiv · Aug 31, 2021Biochemistry