W. Cao

Development of a Two-Leaf Photosynthetic Model Sensitive to Chlorophyll and Its Coupling with a Wheat Growth Model

This study develops a two-leaf photosynthetic model sensitive to chlorophyll and couples it with a wheat growth model to better understand the effects of nitrogen dynamics and diffuse light on photosynthesis.

Morphomechanic tuning of ERK by actin-TFII-IΔ regulates cell identity

The paper shows that actin-TFII-IΔ modulates ERK activity through cell height to direct cell fate during reprogramming.

ABLs and TMKs are co-receptors for extracellular auxin

The paper identifies ABL1 and ABL2 as new auxin receptors that function with TMKs as co-receptors for extracellular auxin, overlapping with but distinct from ABP1.

Multiple genes evolved for fungal septal pore plugging identified via large-scale localization and functional screenings

The paper identifies 23 genes involved in fungal septal pore plugging through genomic comparisons, localization analysis, and functional screening.

The rVSV-EBOV vaccine provides limited cross-protection against Sudan virus in guinea pigs

This study shows that the rVSV-EBOV vaccine provides limited cross-protection against Sudan virus in guinea pigs, while the rVSV-SUDV vaccine offers complete protection.

Improving Lab Culture Through Self-Assessment: A Case Study

The paper describes a self-assessment process to improve lab culture through surveys and group discussions, resulting in a 12% increase in member satisfaction.

MAL suppresses OSCC tumorigenesis by maintaining epithelial cell differentiation

This study shows MAL suppresses OSCC by maintaining epithelial differentiation, with MAL and its co-functional genes as potential biomarkers for prevention and therapy.

Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity

This paper introduces self-assembling short duplex RNAs that induce interferon production and inhibit multiple respiratory viruses.

Lin28a rejuvenates muscle stem cells via mitochondrial optimization

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.

The STAT5-IRF4-BATF pathway drives heightened epigenetic remodeling in naïve CD4+ T cell responses of older adults

The paper examines age-related changes in T cell responses by analyzing transcriptional and epigenetic profiles of naive CD4+ T cells from young and older adults, identifying increased epigenetic remodeling and effector cell differentiation.

A Recurring Chemogenetic Switch for Chimeric Antigen Receptor T Cells

This paper introduces a chemogenetic switch for CAR-T cells using HCV-NS3 protease, enabling controlled activation through ASV concentration modulation.

Exposure route, sex, and age influence disease outcome in a golden Syrian hamster model of SARS-CoV-2 infection

This study investigates how exposure route, sex, and age affect SARS-CoV-2 pathogenesis in golden Syrian hamsters, finding significant differences in disease outcomes.

Cellular Activities of SARS-CoV-2 Main Protease Inhibitors Reveal Their Unique Characteristics

This paper evaluates the cellular potency of SARS-CoV-2 MPro inhibitors using a fluorescent flow cytometry assay, revealing that most inhibitors have weak cellular activity despite strong antiviral effects.

Enteric coronavirus infection and treatment modeled with an immunocompetent human intestine-on-a-chip

This paper uses an intestine-on-a-chip model to study NL63 coronavirus infection effects on the human intestine and tests antiviral treatments.

Influence of age on functional memory T cell diversity

The paper identifies CD73-expressing memory T cells that decline with age and are functionally distinct, with potential interventions to improve immune memory in older adults.

Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum N- and O-Glycopeptide Data

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

Inhibition of HSP90 reversed STAT3 mediated muscle wasting induced by cancer cachexia

The paper shows that inhibiting HSP90 reduces STAT3-mediated muscle wasting in cancer cachexia by disrupting the HSP90/STAT3/FOXO1 axis.

In vivo lentiviral vector gene therapy to cure hereditary tyrosinemia type 1 and prevent development of precancerous and cancerous lesions

This study cures hereditary tyrosinemia type 1 in pigs using in vivo lentiviral gene therapy, preventing liver fibrosis and tumorigenic pathways.

Single-PanIN-seq Unveils that ARID1A Deficiency Promotes Pancreatic Tumorigenesis by Attenuating KRAS Induced Senescence

The paper identifies ARID1A deficiency's role in promoting pancreatic tumorigenesis by reducing KRAS-induced senescence through upregulation of ALDH1A1 in mouse PanIN models.

An improved comprehensive strategy for deep and quantitative N-glycomics based on optimization of sample preparation, isotope-based data quality control and quantification, new N-glycan libraries and new algorithms

The paper presents an improved strategy for deep N-glycomics with optimized sample prep, isotope-based QC, new libraries, and algorithms, but the manuscript was withdrawn due to incomplete data.

Biomechanical Characterization of SARS-CoV-2 Spike RBD and Human ACE2 Protein-Protein Interaction

This study quantifies the biophysical differences in SARS-CoV-2 and SARS-CoV-1 RBD-ACE2 interactions using single-molecule force spectroscopy and SMD simulations, revealing a key N-glycan interaction in SARS-CoV-2 that enhances binding affinity.

Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics

This paper demonstrates the use of human organ chips to rapidly repurpose therapeutics for viral pandemics, identifying amodiaquine as a potential treatment for SARS-CoV-2.

Corona exchange dynamics on carbon nanotubes by multiplexed fluorescence monitoring

This study measures real-time DNA and protein exchange dynamics on carbon nanotubes in solution, showing fibrinogen binds more strongly than albumin and affects dopamine sensor response.

Genome assembly of the A-group Wolbachia in Nasonia oneida and phylogenomic analysis of Wolbachia strains reveals patterns of genome evolution and lateral gene transfer

Global analysis of epigenetic heterogeneity identifies divergent drivers of esophageal squamous cell carcinoma

The paper identifies epigenetic drivers of esophageal squamous cell carcinoma through multi-omics analysis, revealing hypomethylation patterns and non-canonical WNT signaling activation.

Active cargo positioning in antiparallel transport networks

The paper studies cargo positioning in antiparallel actin networks using colloidal beads and myosin motors, finding that beads accumulate at regions of neutral polarity with motor-dependent precision.

NAD+ treatment can increase directly the antioxidant capacity of rotenone-treated differentiated PC12 cells

This study shows NAD+ treatment increases antioxidant capacity in rotenone-treated PC12 cells by raising the GSH/GSSG ratio, suggesting a direct mechanism for its protective effects against oxidative stress.

SIRT2, ERK and Nrf2 mediate NAD+ treatment-induced increase in the antioxidant capacity of differentiated PC12 cells under basal conditions

This study shows NAD+ increases antioxidant capacity in PC12 cells through SIRT2, ERK, and Nrf2 pathways under basal conditions.

Microbial Cells Harboring a Mitochondrial Gene Are Capable of CO2 Capture

This study identifies a mitochondrial gene, OG1, capable of CO2 capture in engineered microorganisms, suggesting its potential for mitigating global warming through biological CO2 capture in barren lands.

Transcription factor SmWRKY1 positively promote the biosynthesis of tanshinones in Salvia miltiorrhiza

This study identifies SmWRKY1 as a positive regulator of tanshinone biosynthesis in Salvia miltiorrhiza by enhancing MEP pathway gene expression.