K. Becker

Comparison of the mechanism of antimicrobial action of the gold(I) compound auranofin in Gram-positive and Gram-negative bacteria

This paper investigates how auranofin affects Gram-positive and Gram-negative bacteria, finding that Gram-negative bacteria are more resistant due to efflux systems and glutathione levels.

Ventricular lymphatic vessel density correlates with mild cardiac remodelling and preserved heart function in moderate murine aortic valve stenosis

This study examines the relationship between ventricular lymphatic vessel density, cardiac remodelling, and heart function in a mouse model of moderate aortic valve stenosis.

In-host evolution of classic to convergent Klebsiella pneumoniae sequence type 147 isolates and impact of associated capsular changes on different morphotypes

This study investigates in-host evolution of Klebsiella pneumoniae sequence type 147 isolates, revealing microevolution from classic to convergent pathotype through plasmid acquisition and capsular changes affecting virulence and morphology.

Temperatures above 37°C increase virulence of a convergent Klebsiella pneumoniae sequence type 307 strain

This study shows that temperatures above 37°C increase hypermucoviscosity and virulence in a convergent Klebsiella pneumoniae strain, potentially due to plasmid-encoded factors and temperature-dependent regulatory changes.

Long-read transcriptome sequencing of CLL and MDS patients uncovers molecular effects of SF3B1 mutations

This study uses long-read transcriptome sequencing to analyze SF3B1 mutations in CLL and MDS patients, revealing common splicing alterations and their impact on disease prognosis.

Klebsiella pneumoniae exhibiting a phenotypic hyper-splitting phenomenon including the formation of small colony variants

The paper describes a Klebsiella pneumoniae strain exhibiting phenotypic hyper-splitting, forming small colony variants and multiple morpho-resistotypes with clinical implications.

Multi-omics investigations uncover unique pathogenic markers in clinical Klebsiella pneumoniae that could be leveraged as novel antimicrobial targets

This study identifies unique pathogenic markers in Klebsiella pneumoniae through multi-omics analysis, suggesting potential novel antimicrobial targets.

Real-time measurements of ATP dynamics via ATeams in Plasmodium falciparum reveal drug-class-specific response patterns

The paper develops fluorescent ATP sensors for Plasmodium falciparum to measure real-time ATP dynamics and identifies drug-class-specific effects on ATP levels.

Haplotype independence contributes to evolvability in the long-term absence of sex in a mite

The paper identifies haplotypic independence as a mechanism enabling long-term survival of an asexual mite species without sex.

Reference genome sequence of the solitary bee Camptopoeum friesei Mocsary, 1894 (Hymenoptera, Andrenidae)

The paper presents the reference genome of the solitary bee Camptopoeum friesei, generated using long-read sequencing and Hi-C, to aid in understanding its ecological specialization and conservation.

Hamsters are a model for post-COVID-19 alveolar regeneration mechanisms: an opportunity to understand post-acute sequelae of SARS-CoV-2

This study shows that Syrian golden hamsters exhibit dysregulated alveolar regeneration after SARS-CoV-2 infection, mirroring post-acute sequelae in humans.

Peroxide antimalarial drugs target redox homeostasis in Plasmodium falciparum infected red blood cells

This paper identifies redox-related protein targets of peroxide antimalarials using chemoproteomics and confirms their impact on redox homeostasis in Plasmodium falciparum.

A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1

The paper identifies LCS3, a compound that induces oxidative stress in lung cancer cells by inhibiting disulfide reductases GSR and TXNRD1, and shows its synergistic effect with glutathione and thioredoxin pathway inhibition.

Computer-Assisted Mitotic Count Using a Deep Learning-based Algorithm Improves Inter-Observer Reproducibility and Accuracy in canine cutaneous mast cell tumors

Anatomy of an Extensively Drug Resistant Klebsiella pneumoniae Outbreak in Tuscany, Italy

This study tracks an NDM-producing K. pneumoniae outbreak in Italy, identifying a high-risk clone with multidrug resistance and a hybrid plasmid linked to hypervirulence.

ABC transporters confer multidrug resistance to Drosophila intestinal stem cells

This study shows that Drosophila intestinal stem cells exhibit multidrug resistance via ABC transporters, a feature conserved from vertebrates.