R. Klopfleisch

Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface

The paper develops methods to collect intestinal interstitial fluid from different segments and shows segment-specific differences in microbiota-derived metabolites, cytokines, and proteins compared to plasma and serum.

Concurrent Ascaris infection modulates host immunity resulting in impaired control of Salmonella infection in pigs

This study shows that Ascaris infection in pigs impairs immune control of Salmonella, leading to higher bacterial burdens and increased susceptibility to coinfection.

Cross-Species Variability in Lobular Geometry and Cytochrome P450 Hepatic Zonation: Insights into CYP1A2, CYP2E1, CYP2D6 and CYP3A4

This study compares lobular geometry and CYP450 zonation across four species using whole slide imaging, identifying species differences and determining the minimum number of lobules needed for statistical analysis.

A Buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72h in mouse femoral fracture models

This study evaluates a new Buprenorphine depot formulation (BUP-Depot) for sustained post-surgical analgesia in mouse femoral fracture models, finding it effective for 72h and comparable to Tramadol in drinking water.

Acute Cytomegalovirus Infection Modulates the Intestinal Microbiota and Targets Intestinal Epithelial Cells

This study shows that acute CMV infection alters gut microbiota and targets intestinal epithelial cells, leading to colitis in immunocompetent hosts.

Cytologic Scoring of Equine Exercise-Induced Pulmonary Hemorrhage (EIPH): Performance of Human Experts and a Deep Learning-Based Algorithm

This study evaluates the diagnostic accuracy and reproducibility of human experts and a deep learning algorithm for scoring exercise-induced pulmonary hemorrhage in horses using bronchoalveolar lavage fluid.

Immune competence and spleen size scale with colony status in the naked mole-rat

This study examines spleen size and immune function in naked mole-rats, finding that enlarged spleens correlate with better anti-microbial profiles and higher social rank.

Computer-Assisted Mitotic Count Using a Deep Learning-based Algorithm Improves Inter-Observer Reproducibility and Accuracy in canine cutaneous mast cell tumors