Author

K. Krishna Kumar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

B. K. Kobilka· 4 shared H. Wang· 3 shared J. M. Mathiesen· 3 shared D. Hilger· 2 shared G. Skiniotis· 2 shared A. El Daibani· 1 shared A. Inoue· 1 shared A. Makriyannis· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBiochemistry

B. K. Kobilka

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Author profile →

4 papers

Recent·Most cited

Negative allosteric modulation of the μ-opioid receptor

E. S. O'Brien, V. A. Rangari, A. El Daibani, S. O. Eans, B. White, H. Wang, Y. Shiimura, K. Krishna Kumar, K. Appourchaux, W. Huang, C. Zhang, J. M. Mathiesen, T. Che, J. P. McLaughlin, S. Majumdar, B. K. Kobilka

This paper identifies a negative allosteric modulator of the μ-opioid receptor that blocks agonist activity and enhances naloxone efficacy, offering potential for safer opioid overdose reversal.

bioRxiv · Sep 8, 2023 · PreprintBiochemistry

Negative allosteric modulation of the glucagon receptor by RAMP2

K. Krishna Kumar, E. O'Brien, C. Habrian, N. R. Latorraca, H. Wang, I. Tuneew, E. Montabana, S. Marqusee, D. Hilger, E. Y. Isacoff, J. M. Mathiesen, B. K. Kobilka

This study shows RAMP2 inhibits GCGR signaling by inducing conformational changes and disorder in the receptor's extracellular domain.

bioRxiv · Aug 30, 2022 · PreprintBiochemistry

Modulation of cannabinoid receptor signaling by endocannabinoids

K. Krishna Kumar, M. J. Robertson, E. Thadhani, H. Wang, C.-M. Suomivuori, A. S. Powers, L. Ji, S. P. Nikas, M. Gerasi, K. Vemuri, R. Dror, A. Inoue, A. Makriyannis, G. Skiniotis, B. K. Kobilka

This study investigates how endocannabinoids modulate CB1 receptor signaling by comparing their activation of Gi1 with synthetic cannabinoids and revealing structural differences in ligand binding.

bioRxiv · Aug 6, 2022 · PreprintBiochemistry

Structural insights into ligand efficacy and activation of the glucagon receptor

D. Hilger, K. Krishna Kumar, H. Hu, M. F. Pedersen, L. Giehm, J. M. Mathiesen, G. Skiniotis, B. K. Kobilka

The paper presents the cryo-EM structure of the glucagon receptor bound to a ligand and G-protein, revealing structural insights into ligand efficacy and activation mechanism.

bioRxiv · Jun 5, 2019 · PreprintBiophysics