L. Ji

The Mechanism Insight into Bacterial Degradation of Pentachlorobiphenyl

This study identifies a new bacterium capable of degrading pentachlorobiphenyl and characterizes its enzymatic, proteomic, and metabolomic responses to the pollutant.

Activating neutrophils by co-administration of immunogenic recombinant modified vaccinia virus Ankara and granulocyte colony-stimulating factor for the treatment of malignant peripheral nerve sheath tumor

This study shows that co-administering immunogenic MVA and G-CSF activates neutrophils to kill MPNST tumors in a murine model.

Class I histone deacetylase complex: structure and functional correlates

The paper reports cryo-EM structures of the Schizosaccharomyces pombe Clr6S complex, revealing its active site and interactions with a nucleosome.

Innate-adaptive IFN cross-talk reprograms myeloid and T cells for antitumor immunity with a second-generation recombinant MVA

This paper describes a second-generation recombinant MVA vaccine that enhances antitumor immunity by reprogramming myeloid and T cells through innate-adaptive IFN cross-talk.

Modulation of cannabinoid receptor signaling by endocannabinoids

This study investigates how endocannabinoids modulate CB1 receptor signaling by comparing their activation of Gi1 with synthetic cannabinoids and revealing structural differences in ligand binding.

Structure of the histone acetyltransferase NuA4 complex

The paper presents a near-atomic structure of the NuA4 complex and shows it has auto-inhibited conformation that becomes active upon substrate and co-factor binding.

NAD precursors cycle between host tissues and the gut microbiome

The paper shows NAD precursors cycle between host tissues and the gut microbiome to maintain NAD homeostasis.

Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression ofPAK3 via miRNA regulation

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

Contrasting patterns and co-occurrence network of soil bacterial and fungal community along depth profiles in cold temperate montane forests of China

This study examines soil bacterial and fungal community patterns and co-occurrence networks along depth and altitude gradients in cold-temperate forests, finding altitude has a stronger impact than depth.

Differential variation of NSCs in root branch orders of Fraxinus mandshurica Rupr. seedlings across different drought intensities and soil substrates

The paper examines how non-structural carbohydrates (NSCs) and fine root traits vary across root branch orders in Fraxinus mandshurica seedlings under different drought and soil conditions.

Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth

This study identifies Klp9's dual role in regulating microtubule sliding and growth during anaphase B spindle elongation in S. pombe.

Seasonal variations in soil fungal communities and co-occurrence networks along an altitudinal gradient in the cold temperate zone of China: A case study on Oakley Mountain

This study examines seasonal variations in soil fungal communities and co-occurrence networks along an altitudinal gradient in a cold temperate zone, finding that altitude has stronger effects than season on community structure and diversity.

A Novel LysR-Type Global Regulator RpvA Controls Persister Formation and Virulence in Staphylococcus aureus

This study identifies RpvA, a LysR-type regulator in S. aureus, which controls persister formation and virulence by modulating metabolism and virulence gene expression.

Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore

The paper develops an iridium(III) dye for tracking mitochondrial dynamics under structured illumination microscopy, revealing new insights into mitochondria-lysosome interactions.

TET-mediated epimutagenesis of the Arabidopsis thaliana methylome

This paper introduces a method to generate DNA methylation variation in Arabidopsis thaliana by expressing a human TET enzyme, leading to hypomethylation and phenotypic changes.

Changes of gene expression but not cytosine methylation are associated with plasticity of male parental care reflecting behavioural state, social context, and individual flexibility

The paper examines gene expression and DNA methylation changes in male burying beetles during parental care, finding that gene expression varies with behavioral state and social context, while DNA methylation does not correlate with gene expression changes.

The evolution of CHROMOMETHYLASES and gene body DNA methylation in plants

This study investigates the evolution of CHROMOMETHYLASES and gene body DNA methylation across plants using transcriptomes and methylomes.