Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and TGFβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritis
W. Chen, Y. Lu, Y. Zhang, J. Wu, A. McVicar, Y. Chen, S. Zhu, G. Zhu, Y. Lu, J. Zhang, M. McConnell, Y.-P. Li
This study shows that Cbfβ deficiency leads to OA by altering Wnt/β-catenin, Hippo/Yap, and TGFβ signaling, and that local Cbfβ overexpression protects against OA in mice.
bioRxiv · Jan 15, 2024Pathology