Author

M. McConnell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:clinical cohort / trial· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. McVicar· 1 shared A. V. Ratushny· 1 shared C. C. Santini· 1 shared D. W. Pierce· 1 shared G. Zhu· 1 shared J. Jeong· 1 shared J. Wu· 1 shared J. Zhang· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperPathology

A. McVicar

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and TGFβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritis

W. Chen, Y. Lu, Y. Zhang, J. Wu, A. McVicar, Y. Chen, S. Zhu, G. Zhu, Y. Lu, J. Zhang, M. McConnell, Y.-P. Li

This study shows that Cbfβ deficiency leads to OA by altering Wnt/β-catenin, Hippo/Yap, and TGFβ signaling, and that local Cbfβ overexpression protects against OA in mice.

bioRxiv · Jan 15, 2024Pathology

Quantitative systems pharmacology modeling of avadomide-induced neutropenia enables virtual clinical dose and schedule finding studies

R. A. Abbiati, M. Pourdehnad, S. Carrancio, D. W. Pierce, S. Kasibhatla, M. McConnell, M. W. B. Trotter, R. Loos, C. C. Santini, A. V. Ratushny

The paper uses QSP modeling to simulate avadomide-induced neutropenia and identify optimal dosing schedules for clinical trials.

The AAPS Journal · Aug 27, 2021Peer-reviewedPharmacology & Toxicology

Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosis

T. Su, Y. Yang, S. Lai, J. Jeong, Y. Jung, M. McConnell, T. Utsumi, Y. Iwakiri

This study uses single-cell RNA sequencing to identify zone-specific transcriptomic changes in liver sinusoidal endothelial cells in cirrhosis, revealing Zone 3 LSECs as most susceptible to damage.

bioRxiv · Mar 18, 2020Cell Biology