Author

N. Ziari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

A. Dillin· 2 shared C. P. Schneider· 2 shared E. Nyangau· 2 shared H. Mohammed· 2 shared H. Palacios· 2 shared L. Peng· 2 shared S. Yuen· 2 shared A. E. Frakes· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersPhysiology

A. Dillin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Small Molecule Protein Assembly Modulators with Pan-Cancer Therapeutic Efficacy

A. F. Lingappa, O. Akintunde, C. Ewald, M. Froehlich, N. Ziari, M. Michon, S. F. Yu, S. Mallesh, J. Lin, A. Kitaygorodskyy, D. Solas, J. C. Reed, J. R. Lingappa, A. Mueller-Schiffmann, C. Korth, , V. R. Lingappa

The paper identifies two small molecules with pan-cancer cytotoxicity and validates their anti-tumor effects in xenograft models, showing they target TRIM28/KAP1-containing complexes involved in cancer survival.

bioRxiv · Sep 28, 2022Cancer Biology

Aging alters the metabolic flux signature of the ER unfolded protein response in vivo in mice

C. P. Schneider, L. Peng, S. Yuen, J. Halstead, H. Palacios, E. Nyangau, H. Mohammed, N. Ziari, A. E. Frakes, A. Dillin, M. Hellerstein

This study shows that aging in mice leads to an exaggerated and less effective endoplasmic reticulum unfolded protein response (UPRER) under stress, with altered metabolic flux patterns in protein synthesis and lipid production.

bioRxiv · Apr 14, 2021Physiology

Metabolic flux signatures of the ER unfolded protein response in vivo reveal decreased hepatic de novo lipogenesis and mobilization of lipids from adipose tissue to liver

C. P. Schneider, L. Peng, S. Yuen, M. Chang, R. Karapetyan, E. Nyangau, H. Mohammed, H. Palacios, N. Ziari, L. K. Joe, A. Frakes, A. Dillin, M. K. Hellerstein

This study uses metabolic labeling and mass spectrometry to analyze UPRER-induced metabolic changes in mouse liver, revealing reduced de novo lipogenesis and lipid mobilization from adipose to liver.

bioRxiv · Oct 29, 2020 · PreprintPhysiology