Author

J. Hooper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 3 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

X. Zeng· 4 shared R. Brocato· 3 shared J. M. Smith· 2 shared L. M. Principe· 2 shared S. A. Kwilas· 2 shared Y. He· 2 shared A. Andrew· 1 shared A. Blanco· 1 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersMicrobiology

X. Zeng

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Mechanism by which Aurora B inhibitors promotes RB and p53-dependent senescence.

S. Vora, A. Andrew, R. P. Kumar, D. Nazareth, M. Fernando, M. J. Jones, Y. He, J. Hooper, N. A. McMillan, J. Urosevic, J. Saeh, J. Travers, B. Gabrielli

This study investigates how Aurora B inhibitors induce polyploidy and shows that higher ploidy states reduce long-term proliferative potential in cells with functional RB and p53.

bioRxiv · Mar 27, 2024 · PreprintCell Biology

Glycogen phosphorylase inhibition alongside taxol chemotherapy synergistically elicits ferroptotic cell death in clear cell ovarian and kidney cancers

T. Khan, Y. He, T. Kryza, J. Gunter, M. Gough, C. Snell, J. Hooper

The paper shows that inhibiting glycogen phosphorylase with CP91149 synergizes with taxol to induce ferroptotic cell death in clear cell ovarian and kidney cancers.

bioRxiv · May 1, 2023 · PreprintCancer Biology

Aerosol Exposure of Cynomolgus Macaques to SARS-CoV-2 Results in More Severe Pathology than Existing Models

S. L. Bixler, C. P. Stefan, A. Jay, F. D. Rossi, K. M. Ricks, C. J. Shoemaker, A. M. Moreau, X. Zeng, J. Hooper, D. Dyer, O. Frick, J. W. Koehler, B. Kearney, N. DiPinto, J. Liu, , M. L. M. Pitt

This study compares aerosol and intranasal SARS-CoV-2 exposure in macaques, finding aerosol exposure in cynomolgus macaques causes more severe disease than other models.

bioRxiv · Apr 27, 2021 · PreprintMicrobiology

Protective efficacy of a SARS-CoV-2 DNA Vaccine in wild-type and immunosuppressed Syrian hamsters

R. Brocato, S. A. Kwilas, R. K. Kim, X. Zeng, L. M. Principe, J. M. Smith, J. Hooper

This study evaluates a SARS-CoV-2 DNA vaccine in Syrian hamsters, showing it is protective in both healthy and immunosuppressed models.

bioRxiv · Nov 10, 2020Microbiology

Small Animal Jet Injection Technique Results in Enhanced Immunogenicity of Hantavirus DNA Vaccines

R. Brocato, S. A. Kwilas, M. D. Josleyn, S. Long, X. Zeng, C. C. Perley, L. M. Principe, B. C. Somerville, M. V. Cohen, J. Hooper

This study shows that using a jet injection device improves the immunogenicity of hantavirus DNA vaccines in hamsters compared to traditional methods.

bioRxiv · Nov 9, 2020Microbiology

Larger organ size caused by obesity is a mechanism for higher cancer risk.

H. Grant, Y. Zhang, L. Li, Y. Wang, S. Kawamoto, S. Penisson, D. F. Fouladi, S. Shayesteh, A. Blanco, S. Ghandili, E. Zinreich, J. S. Graves, S. Park, S. Kern, J. Hooper, , C. Tomasetti

This study shows that obesity increases organ size, which correlates with higher cancer risk due to more cells at risk of becoming cancerous.

bioRxiv · Jul 27, 2020 · PreprintCancer Biology

Disruption of Adaptive Immunity Enhances Disease in SARS-CoV-2 Infected Syrian Hamsters

R. Brocato, L. Principe, R. Kim, X. Zeng, J. Williams, Y. Liu, R. Li, J. Smith, J. Golden, D. Gangemi, S. Youssef, Z. Wang, J. Glanville, J. Hooper

This study shows that disrupting adaptive immunity in Syrian hamsters worsens SARS-CoV-2 disease, but a neutralizing antibody reduces infection even in immunosuppressed animals.

bioRxiv · Jun 19, 2020Microbiology