BiochemistrybioRxiv
Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism
Q. Liu, A. Gupta, A. Okesli-Armlovich…·C. Khosla
The paper identifies DHODH as a target of GSK983 and shows that combining it with pyrimidine salvage inhibitors like CPU enhances antiviral efficacy against dengue virus.
DOI 10.1016/j.chembiol.2020.05.002