Author

M. Levesque

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Biochemistry· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:gene regulatory network inference· 2 Research Focus:metabolism & bioenergetics· 2 Approach:statistical model· 2

Frequent Co-Authors

R. Dummer· 3 shared C. Kenny· 2 shared O. Eichhoff· 2 shared P. F. Cheng· 2 shared R. Cornell· 2 shared A. Aloia· 1 shared A. Bileck· 1 shared A. Cartier· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersCancer Biology

R. Dummer

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The genetic evolution of acral melanoma

M. Wang, S. Fukushima, Y.-S. Sheen, E. Ramelyte, N. Cruz Pacheco, C. Shi, S. Liu, I. Banik, J. D. Aquino, M. Sangueza Acosta, M. Levesque, R. Dummer, J.-Y. Liau, C.-Y. Chu, A. H. Shain, , B. C. Bastian

This study analyzes exome sequencing data from acral melanoma patients to identify distinct genetic evolution patterns compared to sun-exposed melanomas.

bioRxiv · Oct 18, 2023Cancer Biology

Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

M. Hooshmandi, V. Sharma, C. T. Perez, R. Sood, K. Simbriger, C. Wong, K. C. Lister, A. U. Guzman, T. D. Bartley, C. Rocha, G. Maussion, E. Nadler, P. M. Roque, I. Gantois, J. Popic, , A. Khoutorsky

The paper shows that suppressing the ISR pathway in excitatory neurons of FXS mice leads to autism-like behaviors and that restoring it rescues these phenotypes.

bioRxiv · Apr 24, 2023 · PreprintNeuroscience

ROS induction as a strategy to target persister cancer cells with low metabolic activity in NRAS mutated melanoma

O. M. Eichhoff, C. I. Stoffel, J. Kaesler, L. Briker, P. Turko, G. Karsai, N. Zila, V. Paulitschke, P. F. Cheng, A. Leitner, A. Bileck, N. Zamboni, A. Irmisch, Z. Balazs, A. Tastanova, , M. Levesque

The paper identifies ROS induction as a strategy to target MEK-inhibitor resistant NRAS-mutated melanoma cells by exploiting their quiescent metabolic state and elevated baseline ROS levels.

bioRxiv · Oct 19, 2022 · PreprintCancer Biology

Engineered high-density lipoprotein particles that chaperone bioactive lipid mediators to combat endothelial dysfunction and thromboinflammation

S. Swendeman, D. Lin, S. Guo, A. Culbertson, A. Kuo, M. Levesque, A. Cartier, T. Seno, A. Schmaier, S. Galvani, A. Inoue, S. Parikh, G. A. FitzGerald, M. Liao, R. Flaumenhaft, T. Hla

This paper constructs engineered HDL-like particles that chaperone bioactive lipids to reduce inflammation and endothelial dysfunction.

bioRxiv · Feb 14, 2022 · PreprintBiochemistry

A DNA Replication-Independent Function of the pre-Replication Complex during Cell Invasion in C. elegans

E. Lattmann, T. Deng, M. Walser, P. Widmer, C. Rexha-Lambert, V. Prasad, O. Eichhoff, M. Daube, R. Dummer, M. Levesque, A. Hajnal

The paper identifies the pre-RC complex as a regulator of cell invasion in C. elegans, independent of its role in DNA replication.

bioRxiv · Jun 10, 2021 · PreprintCell Biology

A neural crest stem cell-like state drives nongenetic resistance to targeted therapy in melanoma

O. Marin-Bejar, A. Rogiers, M. Dewaele, J. Femel, P. Karras, J. Pozniak, G. Bervoets, N. Van Raemdonck, D. Pedri, T. Swings, J. Demeulemeester, S. Vander Borght, F. Bosisio, J. J. van den Oord, I. Vanden Bempt, , J.-C. Marine

This study identifies a neural crest stem cell-like state in melanoma minimal residual disease that drives nongenetic resistance to MAPK-targeted therapy and shows that targeting FAK/SRC signaling can delay relapse.

bioRxiv · Dec 15, 2020 · PreprintCancer Biology

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma

N. R. Campbell, A. Rao, X. Zhang, M. Baron, S. Heilmann, M. Deforet, C. Kenny, L. Ferretti, T.-H. Huang, M. Garg, J. Nsengimana, E. Montal, M. Tagore, M. Hunter, J. Newton-Bishop, , R. White

This study shows that melanoma metastasis is promoted by heterotypic clusters formed between proliferative and invasive cell states, mediated by TFAP2.

bioRxiv · Aug 24, 2020 · PreprintCancer Biology

MITF reprograms the extracellular matrix and focal adhesion in melanoma

R. Dilshat, V. Fock, C. Kenny, I. Gerritsen, R. M. J. Lasseur, O. Eichhoff, J. Travnickova, P. Cerny, K. Moller, S. Sigurbjornsdottir, K. Kirty, B. O. Einarsdottir, P. F. Cheng, M. Levesque, R. Cornell, , E. Steingrimsson

This study shows MITF represses ECM and focal adhesion genes in melanoma, affecting cell morphology and matrix interactions, with reversible effects observed upon MITF knockdown.

bioRxiv · Jul 14, 2020Cancer Biology