M. Sander

Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2

This study identifies SIRT2 as a regulator of β-cell proliferation, showing its role in controlling β-cell expansion during hyperglycemia while preserving feedback mechanisms.

Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

This study shows that engineered vasculature enhances the function of stem cell-derived islet organoids by improving calcium influx and insulin secretion in beta-cells.

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

The paper analyzes single-cell data to understand gene regulation in stem cell-derived pancreatic islets and identifies factors affecting beta-cell maturation and proliferation.

A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction

This paper develops a vascularized 3D model of human pancreatic islets to study immune cell interactions and islet destruction in diabetes.

Systemic LSD1 inhibition prevents aberrant remodeling of metabolism in obesity

This study shows that systemic LSD1 inhibition reduces obesity-related metabolic issues like NAFLD and improves insulin sensitivity in mice without affecting lean mice.

A missense KCNQ1 Mutation Impairs Insulin Secretion in Neonatal Diabetes

This study identifies a KCNQ1 mutation causing neonatal diabetes by impairing β-cell function and survival through electrophysiological and transcriptomic analyses.

Improved freshwater macroinvertebrate detection from eDNA through minimized non-target amplification

This study improves freshwater macroinvertebrate detection from eDNA by designing a new primer that reduces non-target amplification, increasing target read percentages and detected taxa.

Symmetry breaking and de-novo axis establishment in hydra: microtubules as a pivotal element

This study investigates symmetry breaking in regenerating hydra spheroids, showing that microtubules, not actin, are critical for establishing polarity and axis formation.

PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response

This study shows PRDM3 suppresses pancreatitis and pancreatic tumorigenesis by modulating inflammation and Kras-driven oncogenesis in acinar cells.

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

This study shows that nutrient-stimulated histone acetylation regulates the islet epigenome to control adaptive insulin secretion, with Lsd1 playing a key role in this process.

Integrated in vivo quantitative proteomics and nutrient tracing reveals age-related metabolic rewiring of pancreatic β-cell function

This study uses in vivo proteomics and nutrient tracing to show age-related metabolic changes in pancreatic β-cells improve glucose-stimulated insulin secretion.