P. Sens

Friction-induced budding of a cancer cell monolayer

This study shows that frictional forces from cancer-associated fibroblasts induce budding in cancer cell monolayers through a purse-string mechanism, driven by a supracellular contractile ring.

Conformational changes of the ABC Transporter BmrA Depend on Membrane Curvature

This study shows that the conformational changes of the bacterial ABC transporter BmrA are influenced by membrane curvature, affecting its activity and conformational states.

Volume regulation in adhered cells: roles of surface tension and cell swelling

The paper extends the pump-leak model to include mechano-sensitive ion transporters, explaining discrepancies in volume changes of adhered cells due to swelling and surface tension effects.

Cell size scaling laws: a unified theory

This paper presents a unified theory explaining cell size scaling laws through the Pump and Leak model, showing how physical constraints govern cellular dimensions and their breakdown in specific biological states.

A mechano-osmotic feedback couples cell volume to the rate of cell deformation

The paper shows that cell volume depends on the rate of deformation, proposing a mechano-osmotic coupling model involving actin cortex and ion fluxes.

Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction

This study shows cancer-associated fibroblasts actively compress cancer cells via actomyosin contractility, altering YAP localization and tumor morphology.

A Minimal Self-Organization model of the Golgi Apparatus

The paper presents a minimal model of Golgi apparatus self-organization, showing anterograde and retrograde transport emerge as asymptotic behaviors of a more complex dynamical system.

Stick-Slip model for actin-driven cell protrusions, cell polarisation and crawling.

The paper develops a stick-slip model to explain cell protrusion, polarisation, and crawling dynamics through mechanical and biochemical feedback.

Glycan processing in the Golgi - optimal information coding and constraints on cisternal number and enzyme specificity

The paper quantitatively analyzes tradeoffs between Golgi cisternal number and enzyme specificity to determine optimal conditions for synthesizing complex glycan distributions.

3D single cell migration driven by temporal correlation between oscillating force dipoles

This study shows that 3D cell migration is driven by synchronized force dipoles at the front and back of the cell, mimicking Purcell's scallop theorem.

Actin shells control buckling and wrinkling of biomembranes

This study shows how varying actin shell thickness in reconstituted systems controls membrane shape changes under volume reduction, revealing a transition between buckling and wrinkling.