Author

A. Ozkan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

D. L. Stolley· 2 shared M. McMillin· 2 shared M. N. Rylander· 2 shared A. Russell· 1 shared B. Schilling· 1 shared C. M. Schürch· 1 shared D. Collyar· 1 shared D. E. Ingber· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBioengineering

D. L. Stolley

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis

M. Strasser, D. L. Gibbs, P. Gascard, J. Bons, J. W. Hickey, C. M. Schürch, Y. Tan, S. Black, P. Chu, A. Ozkan, N. Basisty, V. Sangwan, J. Rose, S. Shah, S. Camilleri-Broet, , L. L. Ferri

This study uses multi-omics analysis to show coordinated changes in epithelial, stromal, and immune compartments during Barrett's Esophagus progression to adenocarcinoma, revealing early appearance of cancer-associated fibroblasts and immunosuppressive microenvironment.

bioRxiv · Jun 8, 2023 · PreprintCancer Biology

Cirrhosis and Inflammation Regulates CYP3A4 Mediated Chemoresistance in Vascularized Hepatocellular Carcinoma-on-a-chip

A. Ozkan, D. L. Stolley, E. Cressman, M. McMillin, T. Yankeelov, M. N. Rylander

This paper develops a vascularized HCC-on-a-chip model to study how cirrhosis and inflammation affect CYP3A4-mediated chemoresistance and treatment efficacy.

bioRxiv · May 4, 2022 · PreprintBioengineering

Tumor Microenvironment Alters Chemoresistance of Hepatocellular Carcinoma Through CYP3A4 Metabolic Activity

A. Ozkan, D. L. Stolley, E. N. K. Cressman, M. McMillin, S. DeMorrow, T. E. Yankeelov, M. N. Rylander

This study shows that HCC chemoresistance to doxorubicin varies with tumor microenvironment stiffness and oxygen levels, mediated by CYP3A4 expression.

bioRxiv · Jan 23, 2021Cancer Biology