Author

J. Rose

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2 Immunology· 2 Biochemistry· 1 Pathology· 1 Plant Biology· 1

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Research Focus:cell type annotation· 10 Assay:proteomics· 8 Research Focus:differential expression· 7 Approach:deep learning· 5 Approach:experimental assay· 5 Organism:human· 5 Organism:mouse· 5 Approach:statistical model· 4

Frequent Co-Authors

B. Schilling· 6 shared J. Bons· 5 shared N. Basisty· 3 shared A. O'Broin· 2 shared J. B. Burton· 2 shared P. Gascard· 2 shared S. Camilleri-Broet· 2 shared S. Shah· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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6 shared papersCell Biology

B. Schilling

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Author profile →

10 papers

Recent·Most cited

Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation

H. Liu, A. Binoy, S. Ren, T. C. Martino, A. E. Miller, C. R. Willis, S. R. Veerabhadraiah, A. Sukul, J. Bons, J. Rose, B. Schilling, M. J. Jurynec, S. Zhu

This study identifies Sirt5's role in regulating chondrocyte metabolism and osteoarthritis through lysine malonylation, showing its dysregulation contributes to OA in aging and obesity.

bioRxiv · Jul 23, 2024Cell Biology

Characterization of SARS-CoV-2 Convalescent Patients' Serological Repertoire Reveals High Prevalence of Iso-RBD Antibodies

N. C. Curtis, S. Shin, A. P. Hederman, R. I. Connor, W. F. Wieland-Alter, S. Ionov, J. Boylston, J. Rose, M. Sakharkar, D. B. Dorman, J. A. Dessaint, L. L. Gwilt, A. R. Crowley, J. Feldman, B. M. Hauser, , J. Lee

This study characterizes the serological repertoire of SARS-CoV-2 convalescent patients, revealing a high prevalence of iso-RBD antibodies that do not recognize prefusion-stabilized S, and shows that vaccination with prefusion-stabilized S reduces their prevalence.

bioRxiv · Sep 8, 2023 · PreprintImmunology

Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis

M. Strasser, D. L. Gibbs, P. Gascard, J. Bons, J. W. Hickey, C. M. Schürch, Y. Tan, S. Black, P. Chu, A. Ozkan, N. Basisty, V. Sangwan, J. Rose, S. Shah, S. Camilleri-Broet, , L. L. Ferri

This study uses multi-omics analysis to show coordinated changes in epithelial, stromal, and immune compartments during Barrett's Esophagus progression to adenocarcinoma, revealing early appearance of cancer-associated fibroblasts and immunosuppressive microenvironment.

bioRxiv · Jun 8, 2023 · PreprintCancer Biology

Dicarboxylic acid supplementation protects from acute kidney injury via stimulation of renal peroxisomal activity

A. C. S. Barbosa, K. E. Pfister, T. Chiba, J. Bons, J. Rose, J. B. Burton, C. D. King, A. O'Broin, V. Young, B. Zhang, B. Sivakama, A. V. Schmidt, R. Uhlean, B. Schilling, E. S. Goetzman, S. Sims-Lucas

This study shows that DC8 supplementation reduces AKI markers and promotes peroxisomal FAO over mitochondrial FAO in mice with kidney injury.

bioRxiv · May 31, 2023Pathology

Helminth infection impacts hematopoiesis

T. Wijshake, J. Wang, J. Rose, M. Marlar-Pavey, J. J. Collins, M. Agathocleous

This study examines how Schistosoma mansoni infection affects hematopoietic stem cells and erythropoiesis in mice, identifying impairments in HSC function and increased spleen erythropoiesis.

bioRxiv · Feb 10, 2023Immunology

In-depth Analysis of the Sirtuin 5-regulated Mouse Brain Acylome using Library-free Data-Independent Acquisitions

J. Bons, J. Rose, R. Zhang, J. B. Burton, C. Carrico, E. Verdin, B. Schilling

This study presents a DIA-based workflow to analyze PTMs in mouse brains, identifying SIRT5-regulated malonylation and succinylation sites and their impact on metabolic and neurodegenerative pathways.

bioRxiv · Aug 6, 2022 · PreprintCell Biology

Data-Independent Acquisition and Quantification of Extracellular Matrix from Human Lung in Chronic Inflammation-Associated Carcinomas

J. Bons, D. Pan, S. Shah, R. Bai, C. Chen-Tanyolac, X. Wang, D. R. Fels Elliott, A. Urisman, A. O'Broin, N. Basisty, J. Rose, V. Sangwan, S. Camilleri-Broet, J. Tankel, P. Gascard, , B. Schilling

The paper develops a proteomic pipeline to analyze ECM remodeling in lung squamous cell carcinoma, identifying 529 differentially expressed proteins and potential biomarkers.

bioRxiv · Aug 5, 2022Cancer Biology

Comprehensive Proteomic Quantification of Bladder Stone Progression in a Cystinuric Mouse Model Using Data-Independent Acquisitions

J. Rose, N. Basisty, T. Zee, C. Wehrfritz, N. Bose, P.-Y. Desprez, P. Kapahi, M. Stoller, B. Schilling

This study uses proteomic analysis in a cystinuria mouse model to identify proteomic changes during bladder stone progression, highlighting key pathways involved in stone growth and recurrence.

bioRxiv · Apr 6, 2021 · PreprintCell Biology

The Genome of the Charophyte Alga Penium margaritaceum Bears Footprints of the Evolutionary Origins of Land Plants

C. Jiao, I. Sørensen, X. Sun, H. Sun, H. Behar, S. Alseekh, G. Philippe, K. P. Lopez, L. Sun, R. Reed, S. Jeon, R. Kiyonami, S. Zhang, A. R. Fernie, H. Brumer, , J. Rose

This study presents the genome of Penium margaritaceum, a charophyte alga, to explore evolutionary features leading to land plant colonization and identifies gene expansions and adaptations related to terrestrialization.

Cell · May 1, 2020Peer-reviewedPlant Biology

Mammalian stringent-like response mediated by the cytosolic NADPH phosphatase MESH1

C.-K. C. Ding, J. Rose, J. Wu, T. Sun, K.-Y. Chen, P.-H. Chen, E. Xu, S. Tian, J. Akinwuntan, Z. Guan, P. Zhou, J.-T. A. Chi

This study identifies MESH1 as a cytosolic NADPH phosphatase that promotes cell survival under ferroptosis by maintaining NADPH levels and induces transcriptional changes resembling bacterial stringent response.

bioRxiv · May 17, 2018Biochemistry