Author

P. Chu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:differential expression· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell-cell communication· 2 Organism:mouse· 2

Frequent Co-Authors

C. M. Schürch· 2 shared G. P. Nolan· 2 shared M. K. Tsai· 2 shared M. M. Winslow· 2 shared S. Black· 2 shared A. B. Pierce· 1 shared A. Bild· 1 shared A. Kalvala· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

C. M. Schürch

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6 papers

Recent·Most cited

Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis

M. Strasser, D. L. Gibbs, P. Gascard, J. Bons, J. W. Hickey, C. M. Schürch, Y. Tan, S. Black, P. Chu, A. Ozkan, N. Basisty, V. Sangwan, J. Rose, S. Shah, S. Camilleri-Broet, , L. L. Ferri

This study uses multi-omics analysis to show coordinated changes in epithelial, stromal, and immune compartments during Barrett's Esophagus progression to adenocarcinoma, revealing early appearance of cancer-associated fibroblasts and immunosuppressive microenvironment.

bioRxiv · Jun 8, 2023 · PreprintCancer Biology

Combinatorial tumor suppressor inactivation efficiently initiates lung adenocarcinoma with therapeutic vulnerabilities

M. Yousefi, G. Boross, C. Weiss, C. W. Murray, J. D. Hebert, H. Cai, E. L. Ashkin, S. Karmakar, L. Andrejka, L. Chen, M. Wang, M. K. Tsai, W.-Y. Lin, C. Li, P. Yakhchalian, , M. M. Winslow

This study identifies RAS/PI3K pathway activation as a common driver in oncogene-negative lung adenocarcinomas and shows these tumors are vulnerable to targeted therapy.

bioRxiv · Oct 20, 2021Cancer Biology

LKB1 inactivation modulates chromatin accessibility to drive metastatic progression

S. E. Pierce, J. M. Granja, M. R. Corces, J. J. Brady, M. K. Tsai, A. B. Pierce, R. Tang, P. Chu, D. M. Feldser, H. Chang, M. C. Bassik, W. J. Greenleaf, M. M. Winslow

This study shows that LKB1 inactivation alters chromatin accessibility, promoting metastatic progression in lung cancer through SOX17 activation.

bioRxiv · Mar 29, 2021Cancer Biology

Genome and time-of-day transcriptome of Wolffia australiana link morphological extreme minimization with un-gated plant growth

T. P. Michael, E. Ernst, N. Hartwick, P. Chu, D. Bryant, S. Gilbert, S. Ortleb, E. L. Baggs, K. S. Sree, K. J. Appenroth, J. Fuchs, F. Jupe, J. P. Sandoval, K. V. Krasileva, L. Borisjuk, , E. Lam

This study analyzes the genome and time-of-day transcriptome of Wolffia australiana to link its extreme morphological minimization with reduced circadian regulation and continuous growth.

bioRxiv · Mar 31, 2020Plant Biology

Phenotypic Switching of Naïve T cells to Immune-suppressive Treg-like Cells by Mutant KRAS

A. Kalvala, P. Wallet, L. Yang, C. Wang, H. Li, A. Nam, A. Nathan, I. Mambetsariev, V. Poroyko, H. Gao, P. Chu, M. Sattler, A. Bild, E. R. Manuel, P. P. Lee, , R. Salgia

The paper shows mutant KRAS induces T cells to become immune-suppressive Treg-like cells through exosomes, sera, or direct transfection, with single-cell sequencing identifying the interferon pathway as the mechanism.

bioRxiv · Sep 11, 2019Cancer Biology

Coordinated cellular neighborhoods orchestrate antitumoral immunity at the colorectal cancer invasive front

C. M. Schürch, S. S. Bhate, G. L. Barlow, D. J. Phillips, L. Noti, I. Zlobec, P. Chu, S. Black, J. Demeter, D. R. McIlwain, N. Samusik, Y. Goltsev, G. P. Nolan

The paper identifies cellular neighborhoods in colorectal cancer that correlate with antitumoral immunity and patient survival.

bioRxiv · Aug 24, 2019Immunology