Author

J. Bons

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Biochemistry· 2 Cancer Biology· 2 Bioengineering· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 10 Assay:proteomics· 10 Approach:experimental assay· 9 Organism:human· 8 Research Focus:differential expression· 6 Research Focus:cell-cell communication· 4 Approach:deep learning· 3 Organism:mouse· 3

Frequent Co-Authors

B. Schilling· 10 shared J. Rose· 5 shared J. B. Burton· 4 shared A. O'Broin· 3 shared J. P. Rose· 3 shared N. Basisty· 3 shared S. K. Patel· 3 shared C. Carapito· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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10 shared papersCell Biology

B. Schilling

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12 papers

Recent·Most cited

Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation

H. Liu, A. Binoy, S. Ren, T. C. Martino, A. E. Miller, C. R. Willis, S. R. Veerabhadraiah, A. Sukul, J. Bons, J. Rose, B. Schilling, M. J. Jurynec, S. Zhu

This study identifies Sirt5's role in regulating chondrocyte metabolism and osteoarthritis through lysine malonylation, showing its dysregulation contributes to OA in aging and obesity.

bioRxiv · Jul 23, 2024Cell Biology

Exosomes Released from Senescent Cells and Circulatory Exosomes Isolated from Human Plasma Reveal Aging-associated Proteomic and Lipid Signatures

S. K. Patel, J. Bons, J. P. Rose, J. R. Chappel, R. L. Beres, M. Watson, C. Webster, J. B. Burton, R. Bruderer, P. Y. Desprez, L. Reiter, J. Campisi, E. Baker, B. Schilling

This study identifies aging-associated proteomic and lipid signatures in exosomes from senescent cells and human plasma, revealing shared biomarkers and pathways linked to senescence and tissue damage.

bioRxiv · Jun 22, 2024Cell Biology

Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis

M. Strasser, D. L. Gibbs, P. Gascard, J. Bons, J. W. Hickey, C. M. Schürch, Y. Tan, S. Black, P. Chu, A. Ozkan, N. Basisty, V. Sangwan, J. Rose, S. Shah, S. Camilleri-Broet, , L. L. Ferri

This study uses multi-omics analysis to show coordinated changes in epithelial, stromal, and immune compartments during Barrett's Esophagus progression to adenocarcinoma, revealing early appearance of cancer-associated fibroblasts and immunosuppressive microenvironment.

bioRxiv · Jun 8, 2023 · PreprintCancer Biology

Precision-engineered biomimetics: the human fallopian tube

A. J. Crawford, A. Forjaz, I. Bhorkar, T. Roy, D. Schell, V. Queiroga, K. Ren, D. Kramer, J. Bons, W. Huang, G. C. Russo, M.-H. Lee, B. Schilling, P.-H. Wu, I.-M. Shih, , D. Wirtz

The paper develops a precision-engineered multi-compartment organoid model of the human fallopian tube validated against a 3D single-cell reference map.

bioRxiv · Jun 6, 2023 · PreprintBioengineering

Dicarboxylic acid supplementation protects from acute kidney injury via stimulation of renal peroxisomal activity

A. C. S. Barbosa, K. E. Pfister, T. Chiba, J. Bons, J. Rose, J. B. Burton, C. D. King, A. O'Broin, V. Young, B. Zhang, B. Sivakama, A. V. Schmidt, R. Uhlean, B. Schilling, E. S. Goetzman, S. Sims-Lucas

This study shows that DC8 supplementation reduces AKI markers and promotes peroxisomal FAO over mitochondrial FAO in mice with kidney injury.

bioRxiv · May 31, 2023Pathology

Localization and Quantification of Post-Translational Modifications of Proteins Using Electron Activated Dissociation Fragmentation on a Fast-Acquisition Time-of-Flight Mass Spectrometer

J. Bons, C. L. Hunter, R. Chupalov, J. Causon, A. Antonoplis, J. P. Rose, B. MacLean, B. Schilling

This study compares electron activated dissociation (EAD) to collision-induced dissociation (CID) for characterizing and quantifying labile protein post-translational modifications using a fast-acquisition mass spectrometer.

bioRxiv · Apr 29, 2023 · PreprintBiochemistry

Deep Coverage and Quantification of the Bone Proteome Provides Enhanced Opportunities for New Discoveries in Skeletal Biology and Disease

J. P. Rose, C. A. Schurman, C. D. King, J. Bons, J. B. Burton, S. K. Patel, A. O'Broin, T. Alliston, B. Schilling

This paper introduces a novel mass spectrometric workflow for deep bone proteome coverage and quantification, identifying key proteins and post-translational modifications relevant to bone aging and disease.

bioRxiv · Nov 20, 2022 · PreprintBiochemistry

Trans-synaptic dwelling of SARS-CoV-2 particles perturbs neural synapse organization and function

E. Partiot, A. Hirschler, S. Colomb, W. Lutz, T. Claeys, F. Delalande, M. S. Deffieu, J. Roels, J. Bons, D. Callon, L. Andreoletti, M. Labrousse, F. M. Jacobs, V. Rigau, B. Charlot, , R. Gaudin

The paper shows that SARS-CoV-2 exposure perturbs neural synapse organization and electrical activity by lodging at trans-synaptic interfaces.

bioRxiv · Sep 13, 2022 · PreprintMicrobiology

In-depth Analysis of the Sirtuin 5-regulated Mouse Brain Acylome using Library-free Data-Independent Acquisitions

J. Bons, J. Rose, R. Zhang, J. B. Burton, C. Carrico, E. Verdin, B. Schilling

This study presents a DIA-based workflow to analyze PTMs in mouse brains, identifying SIRT5-regulated malonylation and succinylation sites and their impact on metabolic and neurodegenerative pathways.

bioRxiv · Aug 6, 2022 · PreprintCell Biology

Data-Independent Acquisition and Quantification of Extracellular Matrix from Human Lung in Chronic Inflammation-Associated Carcinomas

J. Bons, D. Pan, S. Shah, R. Bai, C. Chen-Tanyolac, X. Wang, D. R. Fels Elliott, A. Urisman, A. O'Broin, N. Basisty, J. Rose, V. Sangwan, S. Camilleri-Broet, J. Tankel, P. Gascard, , B. Schilling

The paper develops a proteomic pipeline to analyze ECM remodeling in lung squamous cell carcinoma, identifying 529 differentially expressed proteins and potential biomarkers.

bioRxiv · Aug 5, 2022Cancer Biology

Comprehensive Profiling of Plasma Exosomes Using Data Independent Acquisitions, New Tools for Aging Cohort Studies

S. K. Patel, R. Bruderer, N. Basisty, J. Bons, P.-Y. Desprez, F. Neri, L. Reiter, J. Campisi, B. Schilling

The paper develops a method to isolate and analyze plasma exosomes, identifying age-related protein and miRNA differences in an aging cohort.

bioRxiv · Feb 27, 2021 · PreprintCell Biology

Studying the fate of tumor extracellular vesicles at high spatio-temporal resolution using the zebrafish embryo

V. Hyenne, S. Ghoroghi, M. Collot, S. Harlepp, J. Bauer, L. Mercier, I. Busnelli, O. Lefebvre, N. Fekonja, P. Machado, J. Bons, F. Delalande, A. I. Amor, S. G. Silva, F. J. Verweij, , J. G. Goetz

This study tracks tumor extracellular vesicles in zebrafish embryos using fluorescent probes, showing their uptake by endothelial cells and macrophages and their behavior in vivo.

bioRxiv · Jul 30, 2018Cell Biology