Cancer BiologybioRxiv
Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence
A. Pantazi, A. Quintanilla, P. Hari…·A. Finch
This study shows that inhibiting LSG1, a GTPase involved in 60S ribosome biogenesis, induces cellular senescence through ER disruption and cholesterol biosynthesis upregulation, with potential therapeutic implications.
DOI 10.1111/acel.12981