Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model
S. Jiang, S. Wu, G. Zhao, Y. He, L. Bao, J. Liu, C. Qin, J. Hou, Y. Ding, J. Wu, J. Yan, L. Humeau, A. Patella, D. B. Weiner, K. Broderick, B. Wang
This study compares a wild-type SARS-CoV-2 spike protein DNA vaccine with an optimized sequence in a mouse model, showing enhanced immune responses and protection against viral challenge.
bioRxiv · Aug 13, 2021Immunology