A. Persat

Spatial control of sensory adaptation modulates mechanosensing in Pseudomonas aeruginosa

This study identifies a spatial mechanism of sensory adaptation in Pseudomonas aeruginosa, revealing how enzyme localization modulates mechanosensing and virulence.

Bacteroides thetaiotaomicron metabolic activity decreases with polysaccharide molecular weight

This study shows that Bacteroides thetaiotaomicron's metabolic activity decreases with increasing polysaccharide molecular weight, affecting bacterial growth and community dynamics.

Archaeal type IV pili stabilize Haloferax volcanii biofilms in flow

This study shows that type IV pili in Haloferax volcanii are essential for biofilm stability under flow, with PilA2 sufficient for normal biofilm structure.

Pseudomonas aeruginosa mechanosensing controls cell polarity during twitching by activating two antagonistic response regulators

This study identifies how two response regulators, PilG and PilH, control cell polarity in Pseudomonas aeruginosa during twitching motility by antagonistically responding to mechanosensing signals.

Fluid flow structures gut microbiota biofilm communities by distributing public goods

The paper shows fluid flow influences gut microbiota biofilm structure by distributing metabolic by-products that enable species interactions.

Pseudomonas aeruginosa contracts mucus to form biofilms in tissue-engineered human airways

This study shows Pseudomonas aeruginosa forms mucus-associated biofilms in human airway models by contracting mucus using type IV pili.

Mechanoregulation of biofilm architecture promotes Pseudomonas aeruginosa antibiotic tolerance.

This study shows that hydrogel mechanical properties influence Pseudomonas aeruginosa biofilm architecture, which in turn affects antibiotic tolerance to colistin.

Engineering Agrobacterium tumefaciens adhesion to target cells.

This paper engineers Agrobacterium tumefaciens to enhance DNA transfer to non-natural hosts by displaying synthetic adhesins on its surface.

The wall-less bacterium Spiroplasma poulsonii builds a polymeric cytoskeleton composed of interacting MreB isoforms

This paper investigates the role of MreB isoforms in Spiroplasma poulsonii, showing they form a polymeric cytoskeleton that maintains cell shape without a cell wall.

Time-resolved scanning ion conductance microscopy for three-dimensional tracking of nanoscale cell surface dynamics

This paper introduces a time-resolved scanning ion conductance microscope (SICM) for high-speed, long-term nanoscale imaging of live cell surface dynamics with sub-5nm axial resolution.

Mechanotaxis directs Pseudomonas aeruginosa twitching motility.

This study identifies mechanotaxis as the mechanism by which Pseudomonas aeruginosa directs twitching motility using the Chp system to control directional migration.

The membrane microenvironment regulates the sequential attachment of bacteria to host cells.

This study shows bacterial adhesion to host cells involves two steps, with the mechanical microenvironment playing a key role in the initial attachment phase.

Biofilms deform soft surfaces and disrupt epithelia.

This study shows biofilms can deform soft substrates and disrupt epithelial cells through mechanical forces, independent of traditional virulence factors.

Filamentation of Vibrio cholerae is an adaptation for surface attachment and biofilm architecture

This study shows that filamentous Vibrio cholerae cells have an advantage in colonizing chitin particles but are outcompeted by matrix-secreting variants in long-term biofilm formation.

Cellular advective-diffusion drives the emergence of bacterial surface colonization patterns and heterogeneity

The paper shows fluid flow represses mixing of bacterial clonal lineages in biofilms, influencing species interactions and evolution through cellular transport mechanisms.

Label-free visualization of type IV pili dynamics by interferometric scattering microscopy

This study uses interferometric scattering microscopy to visualize type IV pili dynamics in Pseudomonas aeruginosa, revealing crawling behavior and rapid retraction after surface attachment.