B. Lemaitre

Duox activation in Drosophila Malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flow

The paper shows Duox in Drosophila Malpighian tubules produces ROS that trigger Upd3 release, which then stimulates gut epithelial renewal via a countercurrent flow system.

A humoral stress response protects Drosophila tissues from antimicrobial peptides

This study identifies Turandot stress proteins that protect Drosophila tissues from antimicrobial peptide-induced damage by binding phosphatidylserine and inhibiting AMP pore formation.

Ecology-relevant bacteria drive the evolution of host antimicrobial peptides in Drosophila

The paper investigates how bacteria in the environment influence the evolution of antimicrobial peptides in Drosophila.

Antimicrobial peptides do not directly contribute to aging in Drosophila, but improve lifespan by preventing dysbiosis

This study investigates the role of antimicrobial peptides (AMPs) in aging in Drosophila, finding that they do not directly affect lifespan but prevent dysbiosis, which improves lifespan.

Drosophila immunity: The Drosocin gene encodes two host defence peptides with pathogen-specific roles

This study identifies two host defence peptides encoded by the Drosocin locus in Drosophila, each with specific roles against different pathogens, and shows how a polymorphism affects susceptibility.

The wall-less bacterium Spiroplasma poulsonii builds a polymeric cytoskeleton composed of interacting MreB isoforms

This paper investigates the role of MreB isoforms in Spiroplasma poulsonii, showing they form a polymeric cytoskeleton that maintains cell shape without a cell wall.

Cecropins contribute to Drosophila host defense against fungal and Gram-negative bacterial infection

This study shows Cecropins in Drosophila are important for defense against Gram-negative bacteria and fungi, using genetic deletion and mutant analysis.

Drosophila antimicrobial peptides and lysozymes regulate gut microbiota composition and abundance

This study shows that antimicrobial peptides and lysozymes in Drosophila regulate gut microbiota composition and abundance, with their effects exacerbated during aging.

Repeated truncation of a modular antimicrobial peptide gene for neural context

The paper shows that Baramicin gene paralogs in Drosophila result from duplication and truncation, producing non-immune products with neural functions.

Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii

The paper reports changes in Drosophila hemolymph proteome upon infection with Spiroplasma poulsonii, revealing chronic Toll pathway activation and candidate proteins controlling bacterial growth.

The Drosophila Baramicin polypeptide gene protects against fungal infection

This study identifies a novel Drosophila antifungal peptide gene, Baramicin A, showing its role in antifungal resistance and immune response.

Rapid molecular evolution of Spiroplasma symbionts of Drosophila

This study examines the rapid molecular evolution of Spiroplasma poulsonii, showing high substitution rates and structural genomic differences between strains.

Comparative RNA-Seq Analyses of Drosophila Plasmatocytes Reveal Gene Specific Signatures In Response To Clean Injury And Septic Injury

This study compares RNA-seq data from Drosophila plasmatocytes under clean injury and microbial infections, identifying differentially expressed genes and metabolic shifts.

Metabolic adjustment of Drosophila hemocyte number and sessility by an adipokine

This study identifies NimB5 as an adipokine that regulates hemocyte number and sessility in Drosophila larvae based on nutritional state.

Blood cells of adult Drosophila do not expand, but control survival after bacterial infection by induction of Drosocin around their reservoir at the respiratory epithelia

The paper identifies the largest reservoir of blood cells in adult Drosophila and shows they control survival after bacterial infection by inducing Drosocin expression in surrounding tissues.

The antimicrobial peptide Defensin cooperates with Tumour Necrosis Factor to drive tumour cell death in Drosophila

This study shows Defensin, an antimicrobial peptide, works with Tumour Necrosis Factor to kill tumour cells in Drosophila, demonstrating an in vivo anti-cancer role for an endogenous AMP.

Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach

This study uses CRISPR to knockout Drosophila AMPs and shows they act synergistically or additively against Gram-negative bacteria and fungi, with specific AMPs targeting specific pathogens.

Two Nimrod receptors, NimC1 and Eater, synergistically contribute to bacterial phagocytosis in Drosophila melanogaster

This study shows that NimC1 and Eater work together in Drosophila to phagocytose bacteria, with Eater handling Gram-positive bacteria and NimC1 also involved in uptake of non-bacterial particles.

More than black and white: complex relationships involving serine proteases regulate the Toll pathway and the melanization response in Drosophila

This study identifies two distinct serine protease pathways regulating melanization and Toll signaling in Drosophila, revealing previously hidden roles of Hayan and Sp7.