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2 papers
Recent·Most cited
D. Shvarev, C. Koenig, N. Susan, L. Langemeyer, S. Walter, A. Perz, F. Froehlich, C. Ungermann, A. Moeller
The paper solves the structure of the CORVET tethering complex using cryo-EM and explains its role in promoting endosome fusion through interactions with Rab5 and PI3P.
bioRxiv · Oct 13, 2023Biochemistry
D. Shvarev, J. Schoppe, C. Koenig, A. Perz, N. Fuellbrunn, S. Kiontke, L. Langemeyer, D. Januliene, K. Schnelle, D. Kuemmel, F. Froehlich, A. Moeller, C. Ungermann
This study determines the structure of HOPS, a lysosomal fusion machinery, revealing its rigid architecture and how it couples membrane tethering with SNARE assembly to facilitate fusion.
bioRxiv · May 5, 2022 · PreprintBiophysics