Author

A. Moeller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:cryo-EM· 6 Research Focus:protein structure prediction· 4 Organism:yeast· 4 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1

Frequent Co-Authors

D. Januliene· 5 shared S. Walter· 4 shared B. M. Esch· 3 shared C. Ungermann· 3 shared D. Shvarev· 3 shared K. Parey· 3 shared L. Langemeyer· 3 shared A. Perz· 2 shared

Activity by Year

2022-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersBiochemistry

D. Januliene

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins.

C. Körner, J.-H. Schäfer, B. M. Esch, K. Parey, S. Walter, D. Teis, D. Januliene, O. Schmidt, A. Moeller, F. Fröhlich

The paper determines the cryo-EM structure of the SPT-Orm2 complex and shows Orm2 has higher inhibitory potential than Orm1, despite similar structures.

bioRxiv · Jan 30, 2024Biochemistry

Conformational variability of cyanobacterial ChlI, the AAA+ motor of magnesium chelatase involved in chlorophyll biosynthesis

D. Shvarev, A. I. Scholz, A. Moeller

The paper determines the structure of the ChlI motor subunit of magnesium chelatase using cryo-EM, revealing its conformational dynamics and oligomerization during ATP turnover.

mBio · Oct 31, 2023Peer-reviewedBiophysics

Structure of the yeast ceramide synthase

J.-H. Schäfer, L. Clausmeyer, C. Körner, B. M. Esch, V. N. Wolf, S. Walter, D. Januliene, A. Moeller, F. Fröhlich

This study determines the structure of the yeast ceramide synthase complex using cryo-EM, revealing its active state and inhibition mechanism by fumonisin B1.

bioRxiv · Oct 24, 2023Biochemistry

Structure of the endosomal CORVET tethering complex

D. Shvarev, C. Koenig, N. Susan, L. Langemeyer, S. Walter, A. Perz, F. Froehlich, C. Ungermann, A. Moeller

The paper solves the structure of the CORVET tethering complex using cryo-EM and explains its role in promoting endosome fusion through interactions with Rab5 and PI3P.

bioRxiv · Oct 13, 2023Biochemistry

Regulatory sites in the Mon1-Ccz1 complex control Rab5 to Rab7 transition and endosome maturation

A.-C. Borchers, M. Janz, J.-H. Schaefer, A. Moeller, D. Kuemmel, A. Paululat, C. Ungermann, L. Langemeyer

bioRxiv · Mar 1, 2023Cell Biology

Structure of the ceramide-bound SPOTS complex

J.-H. Schafer, C. Korner, B. M. Esch, S. Limar, K. Parey, S. Walter, D. Januliene, A. Moeller, F. Frohlich

The paper reports cryo-EM structures of the yeast SPT complex with Tsc3, Orm1, and Sac1, revealing ceramide-dependent inhibition and co-regulation of sphingolipid and sterol metabolism.

bioRxiv · Feb 3, 2023Biochemistry

Structure of the lysosomal membrane fusion machinery

D. Shvarev, J. Schoppe, C. Koenig, A. Perz, N. Fuellbrunn, S. Kiontke, L. Langemeyer, D. Januliene, K. Schnelle, D. Kuemmel, F. Froehlich, A. Moeller, C. Ungermann

This study determines the structure of HOPS, a lysosomal fusion machinery, revealing its rigid architecture and how it couples membrane tethering with SNARE assembly to facilitate fusion.

bioRxiv · May 5, 2022 · PreprintBiophysics

Tracing the substrate translocation mechanism in P-glycoprotein

T. Gewering, D. Waghray, K. Parey, H. Jung, N. N. B. Tran, J. Zapata, P. Zhao, H. Chen, D. Januliene, G. Hummer, I. L. Urbatsch, A. Moeller, Q. Zhang

This study reveals the substrate translocation mechanism in P-glycoprotein by determining cryoEM structures and using molecular dynamics simulations to identify conformational changes in TM1 that regulate transport.

bioRxiv · Apr 28, 2022 · PreprintBiophysics