A. Prestel

A suicidal and extensively disordered luciferase with a bright luminescence

This paper investigates the structure and mechanism of Gaussia luciferase, revealing its disordered structure and identifying key residues for light production and inactivation.

DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2

This study shows DNA binding alters the conformational dynamics and accessibility of the IDR in Sox2, affecting activation domains and transcription.

Checkpoint activation by Spd1: a competition-based system relying on tandem disordered PCNA binding motifs

The paper identifies a PIP-box motif in Spd1 that competes with another PCNA binding site to regulate checkpoint activation in yeast.

A flexible loop in the paxillin LIM3 domain mediates direct binding to integrin β3

This study identifies a direct interaction between paxillin and integrin β3 cytoplasmic tail via a flexible loop in the LIM3 domain, revealing an alternative signaling pathway.

Slow conformational changes in the rigid and highly stable chymotrypsin inhibitor 2

The paper investigates how mutations affect slow conformational dynamics and stability in chymotrypsin inhibitor 2, finding that the excited state population correlates with protein stability.

Structural characterization of human tryptophanhydroxylase 2 reveals L-Phe as the superior regulatorydomain ligand relevant for serotonin biosynthesis

This study determines the structure of TPH2's regulatory domain with L-Phe and shows it is a better ligand than L-Trp, revealing dynamic behavior in the tetramer.

Deciphering the alphabet of disorder -- Glu and Asp act differently on local but not global properties

This study compares the functional and structural differences between glutamate and aspartate in intrinsically disordered proteins using experimental and computational methods.

Double mutant of chymotrypsin inhibitor 2 stabilized through increased conformational entropy

The paper investigates how mutations in CI2 affect conformational dynamics and stability, finding that increased native state entropy correlates with enhanced stability in double mutants.

Dynamic NHE1-Calmodulin complexes of varying stoichiometry and structure regulate Ca2+-dependent NHE1 activation

The paper identifies multiple NHE1:CaM complex states with varying stoichiometry and structure, showing how Ca2+ and phosphorylation regulate NHE1 activation.