P. Harris

Dissecting Mechanisms of Ligand Binding and Conformational Changes in the Glutamine-Binding Protein

This study investigates the ligand binding mechanism of GlnBP in E. coli, finding that conformational changes and ligand binding are correlated, and that the induced-fit mechanism is more consistent with the data than conformational selection.

Fluorogenic Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide Activated SIRT7

This study develops fluorogenic assays and cyclic peptide inhibitors to probe SIRT7 activity and selectivity, revealing its monomeric structure and substrate preferences.

Streptomyces alleviate abiotic stress in plant by producing pteridic acids

This study identifies pteridic acids produced by Streptomyces that alleviate drought and salinity stress in Arabidopsis by promoting root growth and inducing stress response genes.

Structural characterization of human tryptophanhydroxylase 2 reveals L-Phe as the superior regulatorydomain ligand relevant for serotonin biosynthesis

This study determines the structure of TPH2's regulatory domain with L-Phe and shows it is a better ligand than L-Trp, revealing dynamic behavior in the tetramer.

Reconstitution of renal cyst formation in 3D culture reveals a role for AMOT and Yap1 in determining cyst size.

The paper shows that Cadherin 8 and YAP1 drive cyst initiation and expansion, respectively, in 3D kidney cultures, with AMOTL1 inhibiting expansion.

Dynamics of Human Serum Transferrin in Varying Physicochemical Conditions Explored by Using Molecular Dynamics Simulations

This study uses molecular dynamics simulations to investigate how pH, salt, and excipient concentrations affect the conformational stability of human serum transferrin.

Investigating Increased CO2 concentration on the pH of various plant species

This study examines the effect of increased CO2 on plant sap pH, finding that selected plants show increased alkalinity rather than decreased pH, indicating a homeostatic mechanism.

Reversible supramolecular assembly of the anti-microbial peptide plectasin into helical non-amyloid fibrils

The paper shows that a triple-mutant of plectasin forms reversible helical non-amyloid fibrils, with high-resolution structure and pH-dependent equilibrium.

A synthetic peptide CTL vaccine targeting nucleocapsid confers protection from SARS-CoV-2 challenge in rhesus macaques

A synthetic peptide vaccine targeting SARS-CoV-2 nucleocapsid protein protected rhesus macaques from viral challenge, reducing pneumonia and viral load.

Anti-IL-6 versus Anti-IL-6R BlockingAntibodies to Treat Acute Ebola Infection inBALB/c Mice: Potential Implications forTreating Cytokine Release Syndrome

This study shows that early IL-6 neutralization with an anti-IL-6 mAb improves outcomes in Ebola-infected mice, suggesting potential benefits for treating cytokine release syndrome.

Structural-stability studies on recombinant human transferrin

This study investigates how formulation conditions affect the stability of recombinant human transferrin by linking conformational changes to stability using thermal, chemical denaturation, SAXS, and MD simulations.

Pathfinder: open source software for analyzing spatial navigation search strategies

Pathfinder is an open-source tool for analyzing spatial navigation strategies, demonstrating its ability to characterize search strategies in mice learning a water maze.

Mapping the bacterial ecology on the phyllosphere of grass hay and the potential hazards of soaking fodder for horse gut health

This study maps bacterial profiles in hay and shows that soaking alters these profiles, increasing bacterial content and potential pathogens, which may contribute to horse health issues.

Dominance of ST131 Escherichia coli carrying blaCTX-M in patients with bloodstream infections caused by cephalosporin-resistant strains in Australia, New Zealand and Singapore: whole genome analysis of isolates from a randomised trial

The paper characterizes multidrug-resistant Escherichia coli from bloodstream infections in Australia, New Zealand, and Singapore, finding ST131 dominates with blaCTX-M ESBLs, particularly blaCTX-M-15.