Author

A. R. Harrington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

M. Sander· 3 shared H. Zhu· 2 shared K. J. Gaulton· 2 shared M. Wortham· 2 shared A. C. Powers· 1 shared B. R. Cross· 1 shared B. Ramms· 1 shared C. M. Metallo· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersPhysiology

M. Sander

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Author profile →

3 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 25, 2022

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

H. Zhu, G. Wang, K.-V. Nguyen-Ngoc…·M. Sander

The paper analyzes single-cell data to understand gene regulation in stem cell-derived pancreatic islets and identifies factors affecting beta-cell maturation and proliferation.

DOI 10.1101/2022.09.25.509355

humanscRNA-seq

𝕏 PostBluesky

PhysiologybioRxivNov 25, 2021

Systemic LSD1 inhibition prevents aberrant remodeling of metabolism in obesity

B. Ramms, D. P. Pollow, H. Zhu…·M. Sander

This study shows that systemic LSD1 inhibition reduces obesity-related metabolic issues like NAFLD and improves insulin sensitivity in mice without affecting lean mice.

DOI 10.2337/db21-1131

mousemetabolomics

𝕏 PostBluesky

PhysiologybioRxivAug 21, 2019

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

M. Wortham, F. Liu, J. Y. Fleischman…·M. Sander

This study shows that nutrient-stimulated histone acetylation regulates the islet epigenome to control adaptive insulin secretion, with Lsd1 playing a key role in this process.

DOI 10.1172/jci165208

mousehuman

𝕏 PostBluesky