Author

C. Gerle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:cryo-EM· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Assay:ATAC-seq· 1 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Kawamoto· 2 shared G. Kurisu· 2 shared A. Filippi· 1 shared A. Godoy-Hernandez· 1 shared A. H. Asseri· 1 shared A. J. Purugganan· 1 shared A. M. Brunati· 1 shared A. Negro· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

A. Kawamoto

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Author profile →

6 papers

Recent·Most cited

Monomer-dimer structural comparison in quinol-dependent nitric oxide reductase reveals a functional basis for superior enzymatic activity in the dimer

C. C. Gopalasingam, H. Egami, H. Shigematsu, M. Sakaue, K. Fukumoto, C. Gerle, M. Yamamoto, Y. Shiro, K. Muramoto, T. Tosha

The paper compares monomer and dimer structures of NmqNOR to show how dimerization enhances enzymatic activity by stabilizing the active site conformation.

bioRxiv · May 16, 2024Biochemistry

Diatom pyrenoids are encased in a protein shell that enables efficient CO2 fixation

G. Shimakawa, M. Demulder, S. Flori, A. Kawamoto, Y. Tsuji, H. Nawaly, A. Tanaka, R. Tohda, T. Ota, H. Matsui, N. Morishima, R. Okubo, W. Wietrzynski, L. Lamm, R. D. Righetto, , Y. Matsuda

This study identifies a protein shell surrounding diatom pyrenoids that enhances CO2 fixation efficiency and reveals its structural and functional role through in vivo and in vitro analyses.

bioRxiv · Oct 25, 2023 · PreprintCell Biology

Large-scale column-free purification of bovine F-ATP synthase

J. Chimari, Y. Morimoto, T. Tsukihara, C. Gerle

This paper describes a column-free purification method for bovine F-ATP synthase, enabling the isolation of stable oligomeric forms at high purity and quantity.

bioRxiv · Jun 1, 2023Biochemistry

Autoinsertion (LAiR): rapid functional reconstitution of integral membrane proteins into lipid bilayers

A. Godoy-Hernandez, A. H. Asseri, A. J. Purugganan, C. Jiko, C. de Ram, H. Lill, M. Pabst, K. Mitsuoka, C. Gerle, D. Bald, D. G. G. McMillan

This paper introduces LAiR, a method for rapidly reconstituting integral membrane proteins into lipid bilayers, showing improved activity, stability, and preservation of protein properties compared to standard techniques.

bioRxiv · Sep 21, 2022Biochemistry

Structure of cyanobacterial photosystem I complexed with Cytochrome c6 and Ferredoxin at 1.97 A resolution

J. Li, N. Hamaoka, F. Makino, A. Kawamoto, Y. Lin, M. Rögner, M. M. Nowaczyk, Y.-H. Lee, K. Namba, C. Gerle, G. Kurisu

The paper presents a high-resolution cryo-EM structure of cyanobacterial photosystem I complexed with Cytochrome c6 and Ferredoxin, revealing binding interactions and a proposed electron transfer mechanism.

bioRxiv · Mar 1, 2022Plant Biology

TRAP1 and cyclophilin D compete at OSCP subunit to regulate enzymatic activity and permeability transition pore opening by F-ATP synthase

G. Cannino, A. Urbani, M. Gaspari, M. Varano, A. Negro, A. Filippi, F. Ciscato, I. Masgras, C. Gerle, E. Tibaldi, A. M. Brunati, G. Lippe, P. Bernardi, A. Rasola

bioRxiv · Dec 6, 2021Cell Biology