The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness
H. Zeng, X. Zhu, Y. Wu, Y. Li, X. Zhou, J. Watzlawik, Y. M. Chen, A. Raybuck, D. Billadeau, V. Shapiro, W. Springer, J. Sun, M. R. Boothby
This study shows that Rag-GTPases regulate B cell metabolism and immunity by restraining TFEB/TFE3 to maintain mitochondrial fitness and support T-independent humoral immunity.
bioRxiv · Feb 26, 2024Immunology