FASlpr gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus
R. Bohat, X. Liang, Y. Chen, C. Xu, N. Zheng, A. Guerrero, R. Jaffery, N. A. Egan, A. Robles, M. J. Hicks, Y. Du, X. Chen, C. Mohan, W. Peng
This study shows that FASlpr gene dosage affects lymphoproliferation and T cell differentiation in lupus models, with heterozygous Faslpr leading to increased autoantibodies and Th1 cell skewing.
bioRxiv · Nov 1, 2023Immunology