A. Guerrero

LRRK2 G2019S mutation suppresses differentiation of Th9 and Treg cells via JAK/STAT3

This study shows that the LRRK2 G2019S mutation impairs Th9 and Treg cell differentiation while enhancing Th2 differentiation through JAK/STAT3 signaling in T cells.

FASlpr gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus

This study shows that FASlpr gene dosage affects lymphoproliferation and T cell differentiation in lupus models, with heterozygous Faslpr leading to increased autoantibodies and Th1 cell skewing.

Reorganization of the Flagellum Scaffolding Induces a Sperm Standstill During Fertilization

This study shows that reorganization of the flagellum's F-actin network during sperm-egg fusion leads to midpiece contraction and motility cessation.

Cardiac glycosides cause selective cytotoxicity in human macrophages and ameliorate white adipose tissue homeostasis

This study shows cardiac glycosides induce cytotoxicity in human macrophages and improve white adipose tissue homeostasis in obese patients.

Description, measurement, and automatic classification of the Plasmodium berghei oocyst morphology during early differentiation

The paper describes the morphological changes of Plasmodium berghei oocysts during differentiation, identifies 5 transitional stages, and develops an automatic classification algorithm.

Sperm chemotaxis is driven by the slope of the chemoattractant concentration field

This study shows that sea urchin sperm chemotaxis depends on the slope of chemoattractant concentration gradients, mediated by coupling two oscillators: the stimulus function and intracellular calcium changes.

Galactose-modified duocarmycin prodrugs as senolytics

This study develops galactose-modified duocarmycin prodrugs that selectively kill senescent cells by targeting lysosomal β-galactosidase, showing therapeutic potential for age-related diseases.

Metabolic and metagenomic profiling of hydrocarbon-degrading microorganisms obtained from the deep biosphere of the Gulf of Mexico

The paper profiles the metabolic and metagenomic characteristics of deep-sea microbes from the Gulf of Mexico using hydrocarbons as their energy source, revealing diverse chemistries and microbial community shifts.

Nanoscale organization of rotavirus replication machineries

This study uses super-resolution microscopy to reveal the nanoscale organization of rotavirus replication machineries, showing seven viral proteins and dsRNA arranged in six concentric layers within viro-plasms.

Concept and in-silico assessment of an algorithm for monitoring cytosolic fluorescent aggregates in cells.

The paper introduces an algorithm for semi-automatic detection and segmentation of spot-like structures in fluorescence images, demonstrating its robustness in simulated and experimental conditions.