Author

A. Singhania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Alvarez-Quilon· 1 shared A. Bonneau Fortin· 1 shared A. O'Garra· 1 shared A. Roulston· 1 shared A. Sette· 1 shared A. Veloso· 1 shared B. Liu· 1 shared B. Peters· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperCancer Biology

A. Alvarez-Quilon

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Author profile →

3 papers

Recent·Most cited

CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature

A. Singhania, P. Dubelko, R. Kuan, W. D. Chronister, K. Muskat, J. Das, E. J. Phillips, S. A. Mallal, G. Seumois, P. Vijayanand, A. Sette, M. Lerm, B. Peters, C. S. Lindestam Arlehamn

This study identifies CD4+CCR6+ T cells as key drivers of the BCG-induced transcriptional response, showing similar immune signatures across individuals.

bioRxiv · Aug 20, 2021Immunology

CCNE1 amplification is synthetic-lethal with PKMYT1 kinase inhibition

D. Gallo, J. T. F. Young, J. Fourtounis, G. Martino, A. Alvarez-Quilon, C. Bernier, N. M. Duffy, R. Papp, A. Roulston, R. Stocco, J. Szychowski, A. Veloso, H. Alam, P. S. Baruah, A. Bonneau Fortin, , D. Durocher

The paper identifies PKMYT1 as a therapeutic target for CCNE1-amplified cancers, showing that its inhibition leads to synthetic lethality and tumor regression in combination with gemcitabine.

bioRxiv · Apr 8, 2021Cancer Biology

A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection

A. Singhania, R. Verma, C. M. Graham, J. Lee, T. Tran, M. Richarsdon, P. Lecine, P. Leissner, M. P. R. Berry, R. J. Wilkinson, K. Kaiser, M. Rodrigue, G. Woltmann, P. Haldar, A. O'Garra

The paper identifies a modular transcriptional signature for active tuberculosis that distinguishes it from latent infection and other diseases, showing dynamic heterogeneity in tuberculosis contacts.

bioRxiv · Jun 5, 2018Immunology