B. Peters

Massively parallel combination screen reveals small molecule sensitization of antibiotic-resistant Gram-negative ESKAPE pathogens

This study uses high-throughput screening to identify small molecules that enhance antibiotic efficacy against multidrug-resistant Gram-negative bacteria.

Early antiviral CD4 and CD8 T cell responses and antibodies are associated with upper respiratory tract clearance of SARS-CoV-2

The paper examines early T cell and antibody responses in COVID-19 patients and finds they correlate with reduced SARS-CoV-2 viral RNA in the upper respiratory tract.

Linked CD4+/CD8+ T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression

This study shows that combining CD4+/CD8+ T cell neoantigen vaccination with immune checkpoint blockade overcomes resistance and enables tumor regression in low TMB cancers.

Identification of differentially recognized T cell epitopes in the spectrum of Mtb infection

The paper identifies differentially recognized T cell epitopes in Mtb infection stages using a proteome-wide screen and Fluorospot assay, revealing epitopes specific to active TB and potential vaccine targets.

Genome-wide characterization of T cell responses to Bordetella pertussis reveals broad reactivity and similar polarization irrespective of childhood vaccination profiles.

This study maps human CD4+ T cell responses to Bordetella pertussis across its genome, revealing broad reactivity and similar polarization regardless of vaccination history.

Disruption of Mitochondrial Quality Control Genes Promotes Caspase-Resistant Cell Survival Following Apoptotic Stimuli

The paper identifies mitochondrial quality control genes that influence cell survival after apoptosis by affecting MOMP heterogeneity and caspase resistance.

CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature

This study identifies CD4+CCR6+ T cells as key drivers of the BCG-induced transcriptional response, showing similar immune signatures across individuals.

Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures

The paper identifies PD-specific gene signatures in peripheral memory T cells by analyzing RNA-seq data from PD patients and healthy controls.

Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees.

The paper analyzes T cell responses to SARS-CoV-2 variants and finds minimal impact on CD4+ and CD8+ T cell reactivity in convalescents and vaccinees.

Phenotyping in the era of genomics: MaTrics a digital character matrix to document mammalian phenotypic traits coded numerically

MaTrics provides a digital matrix of mammalian phenotypes linked to genomes, highlighting knowledge gaps and enabling genomic-phenomic comparisons.

TCRMatch: Predicting T-cell receptor specificity based on sequence similarity to previously characterized receptors

TCRMatch predicts T-cell receptor specificity by comparing sequence similarity to known epitope-specific receptors in the IEDB.

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

The paper identifies SARS-CoV-2 epitopes recognized by CD4+ and CD8+ T cells in COVID-19 patients and develops epitope megapools for their detection.

Immunological memory to SARS-CoV-2 assessed for up to eight months after infection

The paper assesses SARS-CoV-2 immune memory components over eight months post-infection, finding varying kinetics in antibodies, B cells, and T cells.

Comparison of HLA ligand elution data and binding predictions reveals varying prediction performance for the multiple motifs recognized by HLA-DQ2.5

This study compares HLA ligand elution data with binding predictions for HLA-DQ2.5, finding discrepancies due to ambiguous MHC restriction and underprediction of certain peptides.

The challenge of distinguishing cell-cell complexes from singlet cells in non-imaging flow cytometry and single-cell sorting

The paper identifies molecular signatures and methods to distinguish cell-cell complexes from singlet cells in flow cytometry data, highlighting their impact on data interpretation.

Benchmarking predictions of MHC class I restricted T cell epitopes

This study benchmarks T cell epitope prediction tools using a comprehensive dataset of vaccinia virus epitopes, finding that neural network-based methods trained on MHC binding and ligand elution data perform best.

A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer

The paper describes a modified Helios mass cytometer protocol that improves data quality and reduces inter-instrument variability in multi-center studies.

No cell is an island: circulating T cell:monocyte complexes are markers of immune perturbations

The paper identifies T cell:monocyte complexes in human blood as biological immune interactions, not technical artifacts, and shows their frequency changes with immune perturbations.

Footprints of antigen processing boost MHC class II natural ligand binding predictions

This study develops MHC class II ligand binding predictors trained on naturally eluted peptides, showing improved performance by incorporating antigen processing rules.