A. Tholey

Protein aggregation is a consequence of the dormancy-inducing membrane toxin TisB in Escherichia coli

This study shows that the membrane toxin TisB in E. coli causes protein aggregation, which enhances cellular dormancy and antibiotic tolerance.

The apoplastic space of two wheat genotypes provide highly different environment for pathogen colonization: Insights from proteome and microbiome profiling

This study compares the apoplastic environment of two wheat genotypes during pathogen infection, revealing differences in microbial composition and defense mechanisms.

A mitochondrial sirtuin shapes the intestinal microbiota by controlling lysozyme expression

This study shows that dSirt4 in Drosophila controls lysozyme expression in the intestine, altering microbiota composition and reducing lifespan.

Bacterial c-di-GMP plays a key role in the evolution of host-association

This study shows that c-di-GMP upregulation enables bacteria to adapt to host-association across diverse species.

Closely related Bacteroides of the murine intestinal microbiota affect each other's growth positively or negatively

The paper tests growth interactions between closely related Bacteroides strains from mice and finds both positive and negative effects, with growth promotion more common than inhibition.

Calpains are required for efficient microtubule detyrosination

This study identifies calpains 1 and 2 as regulators of microtubule detyrosination, independent of vasohibin, suggesting they control an unknown tubulin carboxypeptidase.

Small protein 26 interacts and enhances glutamine synthetase activity in Methanosarcina mazei

This study identifies and characterizes sP26, a small protein in Methanosarcina mazei that interacts with and enhances glutamine synthetase activity under nitrogen limitation.

The inducible response of the nematode Caenorhabditis elegans to members of its natural microbiome across development and adult life

This study investigates how C. elegans responds to its native microbiome across development and adult life, identifying key molecular processes and regulatory mechanisms.

Neolithic and Medieval virus genomes reveal complex evolution of Hepatitis B

This study analyzes three ancient HBV genomes from European skeletons, showing HBV circulation for 7000 years and distinct lineages that may have gone extinct.