M. Knop

FoxO factors preserve airway epithelial homeostasis by coordinating adaptive stress responses

The paper shows FoxO factors in Drosophila, mouse, and human airway epithelial cells respond to stressors by nuclear translocation, with FoxO-dependent stress pathways altered in asthma across species.

A mitochondrial sirtuin shapes the intestinal microbiota by controlling lysozyme expression

This study shows that dSirt4 in Drosophila controls lysozyme expression in the intestine, altering microbiota composition and reducing lifespan.

Components of TOR and MAP kinase signaling control chemotropism and pathogenicity in the fungal pathogen Verticillium dahliae

This study identifies key regulators of chemotropism in Verticillium dahliae, showing their roles in nutrient sensing, plant signal detection, and pathogenicity.

Conidial fusion in the asexual fungus Verticillium dahliae

This study identifies and characterizes conidial fusion in Verticillium dahliae via CATs, showing it depends on specific kinases and NADPH oxidase, and enables non-sexual genetic interactions.

Hex1, the Major Component of Woronin Bodies, is Required for Normal Development, Pathogenicity and Stress Response in the Plant Pathogenic Fungus Verticillium dahliae

This study identifies Hex1 as a critical protein in Verticillium dahliae, showing its roles in growth, stress response, and pathogenicity through genetic analysis and functional assays.

SWR1 Chromatin Remodeling Complex Prevents Mitotic Slippage during Spindle Position Checkpoint Arrest

This study identifies the SWR1 chromatin-remodeling complex as essential for maintaining prolonged spindle position checkpoint (SPOC) arrest, preventing mitotic slippage in budding yeast.

Single-color Fluorescence Lifetime Cross-Correlation Spectroscopy in vivo

This paper introduces single-color fluorescence lifetime cross-correlation spectroscopy (sc-FLCCS) as an alternative to dual-color FCCS, using lifetime differences to measure protein interactions in vivo with reduced error sources.

CRISPR-Cas12a-assisted PCR tagging of mammalian genes

This paper describes a method for efficient endogenous gene tagging in mammalian cells using CRISPR-Cas12a and PCR cassettes, achieving up to 60% tagging efficiency with selection.

Extensive 5'-Surveillance Guards Against Non-Canonical NAD-Caps of Nuclear mRNAs in Yeast

The paper identifies NAD-RNAs in yeast, showing they are abundant, short, and guarded by decapping enzymes, with in vitro evidence of translational rejection.

Mechanisms of up-regulation of Ubiquitin-Proteasome activity in the absence of NatA dependent N-terminal acetylation

The paper investigates how UPS activity increases in NatA mutants and identifies mechanisms involving Rpn4 regulation, E3 ligase abundance, and Tom1's role as an E4 ligase.

CDK1 couples proliferation with protein synthesis

This study identifies CDK1 as a regulator of translation that couples cell proliferation with protein synthesis by modulating 5TOP mRNA translation through LARP1.

ESCRT machinery mediates selective microautophagy of endoplasmic reticulum

This study identifies the ESCRT machinery and Nem1-Spo7 phosphatase complex as key components mediating micro-ER-phagy in yeast, distinguishing it from macro-ER-phagy.