H. Schulenburg

Variation in the response to antibiotics and life-history across the major Pseudomonas aeruginosa clone type (mPact) panel

The paper evaluates antibiotic resistance and life-history traits across 20 Pseudomonas aeruginosa strains to identify adaptive strategies and inform new treatment approaches.

Gut-associated functions are favored during microbiome assembly across C. elegans life

This study examines microbiome assembly dynamics in C. elegans, showing increased gut-associated functions and enrichment of specific bacterial genera over the host's lifetime.

Environmental selection overrides host selection in a horizontally acquired microbiota

The paper shows that environmental selection can override host adaptation in a two-member microbiota community of Pseudomonas and Ochrobactrum.

The intricate triangular interaction between protective microbe, pathogen, and host genetics determines fitness of the metaorganism

This study investigates how host genetics, a protective microbe, and a pathogen interact to influence the fitness of the C. elegans metaorganism.

Host and microbiome jointly contribute to adaptation to a complex environment

This study shows that both host and microbiome contribute to adaptation in a novel environment using C. elegans and compost mesocosms.

Bacterial c-di-GMP plays a key role in the evolution of host-association

This study shows that c-di-GMP upregulation enables bacteria to adapt to host-association across diverse species.

Phylogroup-specific variation shapes the clustering of antimicrobial resistance genes and defence systems across regions of genome plasticity

This study examines phylogroup-specific evolutionary dynamics in Pseudomonas aeruginosa genomes, revealing distinct pangenome characteristics and distribution patterns of antimicrobial resistance genes and defence systems.

The ESKAPE mobilome contributes to the spread of antimicrobial resistance and CRISPR-mediated conflict between mobile genetic elements

The paper analyzes MGEs in ESKAPE pathogens, showing their role in AMR spread and CRISPR-mediated conflicts among mobile elements.

High potency of sequential therapy with only beta-lactam antibiotics

This study shows that sequential therapy with only beta-lactam antibiotics can increase bacterial population extinction by reducing spontaneous resistance and cross-resistance.

Modeling host-associating microbes under selection

The paper models microbial populations in a two-compartment host-environment system to analyze selection pressures on replication and migration rates.

CeMbio - The C. elegans microbiome resource

The paper introduces CeMbio, a simplified natural microbiota for C. elegans, enabling causal studies of host-microbiome interactions through a resource with culturable strains and associated tools.

How long do Red Queen dynamics survive under genetic drift? A comparative analysis of evolutionary and eco-evolutionary models

This study compares evolutionary and eco-evolutionary models of Red Queen dynamics, finding that ecological dynamics and local competition accelerate genotype extinction compared to fixed population size models.

Hotspot Dosages of Most Rapid Antibiotic Resistance Evolution

This study investigates how antibiotic resistance evolves in E. coli under varying erythromycin dosages, finding that resistance increases most rapidly just below the minimal inhibitory concentration.

Neutrality in the Metaorganism

This study shows that microbiota community structure across various host organisms aligns with neutral model predictions, suggesting neutral processes rather than host selection primarily shape microbial communities after colonization.

Bdellovibrio and Like Organisms are Predictors of Microbiome Diversity in distinct Host Groups

The paper shows that Bdellovibrio and like organisms (BALOs) are associated with increased microbiome diversity in various host groups.

Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms

The functional repertoire encoded within the native microbiome of the model nematode Caenorhabditis elegans

The paper analyzes the metabolic capabilities of the native microbiome of C. elegans and shows it can synthesize all essential nutrients for the nematode.

The inducible response of the nematode Caenorhabditis elegans to members of its natural microbiome across development and adult life

This study investigates how C. elegans responds to its native microbiome across development and adult life, identifying key molecular processes and regulatory mechanisms.

Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa

This study tests the evolutionary stability of collateral sensitivity in Pseudomonas aeruginosa, finding that resistance to one antibiotic often leads to hypersensitivity to another, but evolutionary outcomes depend on drug order.