Author

A. Tovy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. G. Guzman· 2 shared C.-w. Chen· 2 shared L. Zhang· 2 shared M. A. Goodell· 2 shared A. C. Daquinag· 1 shared A. G. Martell· 1 shared A. Nussenzweig· 1 shared A. R. Cox· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

A. G. Guzman

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells

L. Zhang, J. I. Hsu, E. D. Braekeleer, C.-w. Chen, T. D. Patel, A. G. Martell, A. G. Guzman, K. Wohlan, S. M. Waldvogel, H. Urya, A. Tovy, E. Callen, R. L. Murdaugh, R. U. Richard, S. Jansen, , M. A. Goodell

This study identifies SOD1 as a synthetic lethal target in PPM1D-mutant leukemia cells through CRISPR/Cas9 screening, revealing a dysregulated redox landscape and potential therapeutic strategy.

bioRxiv · Aug 31, 2023Cancer Biology

Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis

A. Tovy, J. M. Reyes, L. Zhang, Y.-H. Huang, C. Rosas, A. C. Daquinag, A. G. Guzman, R. Ramabadran, C.-W. Chen, T. Gu, S. Gupta, L. Ortinau, D. Park, A. R. Cox, R. E. Rau, , M. A. Goodell

This study shows that loss of DNMT3A causes obesity by disrupting adipogenesis and triggering inflammation in adipose tissue.

eLife · May 30, 2022Peer-reviewedCell Biology