SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells
L. Zhang, J. I. Hsu, E. D. Braekeleer…·M. A. Goodell
This study identifies SOD1 as a synthetic lethal target in PPM1D-mutant leukemia cells through CRISPR/Cas9 screening, revealing a dysregulated redox landscape and potential therapeutic strategy.