Author

M. A. Goodell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. M. Reyes· 3 shared A. G. Guzman· 2 shared A. Tovy· 2 shared C.-w. Chen· 2 shared L. Zhang· 2 shared R. E. Rau· 2 shared A. Brunet· 1 shared A. C. Daquinag· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCell Biology

J. M. Reyes

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells

L. Zhang, J. I. Hsu, E. D. Braekeleer, C.-w. Chen, T. D. Patel, A. G. Martell, A. G. Guzman, K. Wohlan, S. M. Waldvogel, H. Urya, A. Tovy, E. Callen, R. L. Murdaugh, R. U. Richard, S. Jansen, , M. A. Goodell

This study identifies SOD1 as a synthetic lethal target in PPM1D-mutant leukemia cells through CRISPR/Cas9 screening, revealing a dysregulated redox landscape and potential therapeutic strategy.

bioRxiv · Aug 31, 2023Cancer Biology

Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis

A. Tovy, J. M. Reyes, L. Zhang, Y.-H. Huang, C. Rosas, A. C. Daquinag, A. G. Guzman, R. Ramabadran, C.-W. Chen, T. Gu, S. Gupta, L. Ortinau, D. Park, A. R. Cox, R. E. Rau, , M. A. Goodell

This study shows that loss of DNMT3A causes obesity by disrupting adipogenesis and triggering inflammation in adipose tissue.

eLife · May 30, 2022Peer-reviewedCell Biology

Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging

L. Liu, S. Kim, M. T. Buckley, J. M. Reyes, J. Kang, L. Tian, T. Wang, A. Lieu, M. Mao, C. Mateo-Rodriguez, H. Ishak, M. Jeong, J. C. Wu, M. A. Goodell, A. Brunet, T. A. Rando

This study examines how exercise affects stem cell compartments and immune cells in aging mice, identifying rejuvenating effects and transcriptomic changes.

bioRxiv · Jan 12, 2022Cell Biology

Modeling IKZF1 lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities

J. H. Rogers, R. Gupta, J. M. Reyes, M. Gundry, G. Medrano, A. Guzman, T. Song, C. Johnson, S. Barnes, C. D. D. Cristobal, L. Brunetti, M. A. Goodell, R. E. Rau

This study models IKZF1 lesions in B-ALL to show distinct chemosensitivity patterns and therapeutic vulnerabilities, identifying cytarabine sensitivity and JAK/STAT upregulation as potential targets.

bioRxiv · May 26, 2020Cancer Biology