B. Cole

Spatial Co-transcriptomics Reveals Discrete Stages of the Arbuscular Mycorrhizal Symbiosis

This study uses spatial transcriptomics to analyze the molecular stages of arbuscular mycorrhizal symbiosis in plant roots.

Single-cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma

The paper identifies LGALS1 as an immunomodulating target in glioblastoma by analyzing GAM-GBM interactions using single-cell RNA sequencing and zebrafish models.

Epidermal GIGANTEA adjusts the response to shade at dusk by directly impinging on PHYTOCHROMEINTERACTING FACTOR 7 function

This study shows that GIGANTEA directly interacts with PIF7 to regulate the shade avoidance response at dusk by modulating its transcriptional activity.

Single-cell molecular profiling using ex vivo functional readouts fuels precision oncology in glioblastoma

The paper introduces PROSPERO, a single-cell assay to evaluate therapy response in glioblastoma by measuring molecular drug responses in fresh tumor samples, revealing limited therapeutic capacity and cellular plasticity.

Single-cell profiling of complex plant responses to Pseudomonas syringae infection

The paper profiles single-cell RNA sequencing data from Arabidopsis infected with Pseudomonas syringae to identify immune and susceptible cell clusters and their transcriptional responses.

Plant Metabolic Network: A multi-species resource of plant metabolic information

The paper updates the Plant Metabolic Network (PMN) with 126 genomes and tools for analyzing metabolism across species, revealing distinct metabolic groups and demonstrating applications in drought tolerance and cell-type specific metabolism.

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

This study uses STIP-Seq to analyze HIV-1 reservoirs and identifies proviral features and cellular sources contributing to plasma viremia in ART-suppressed individuals.

Extensive characterization of HIV-1 reservoirs reveals links to plasma viremia before and during analytical treatment interruption

This study characterizes HIV-1 reservoirs in four individuals during treatment interruption, identifying proviruses linked to plasma viremia and showing their role in viral rebound.