K. Zhao

ALS-causing SOD1 mutations H46R and G85R form similar novel amyloid fibril structures and promote ferroptosis in cells

This study shows that two ALS-causing SOD1 mutations form similar amyloid fibrils that promote ferroptosis in neuronal cells.

Optimal CXCR5 Expression during Tfh Maturation Involves the Bhlhe40-Pou2af1 Axis

This study identifies the Bhlhe40-Pou2af1 axis as a transcriptional regulator of CXCR5 expression in Tfh cells, independent of the Bcl6-Blimp1 pathway.

Small RNA Analysis of Virus-virus Interaction between Two Orthotospoviruses

This study uses small RNA sequencing to investigate how INSV affects TSWV processing and plant responses during their antagonistic interaction.

Physical fitness and motor competence performance characteristics of elite Chinese youth athletes from four track and field throwing disciplines - a cross sectional study

Modification of social cheating facilitates the stabilization and chronic infection of polymorphic Pseudomonas aeruginosa population

The paper shows that evolution in Pseudomonas aeruginosa populations selects for cheater mutants that modify social cooperation to stabilize chronic infections and reduce host immune response.

NDC80 status pinpoints mitotic kinase inhibitors as emerging therapeutic options in clear cell renal cell carcinoma

The paper identifies NDC80 as a predictor of ccRCC progression and shows that NDC80-high tumors are sensitive to mitotic kinase inhibitors.

Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence

This study determines the structure of RsmZ in complex with RsmA, revealing how RsmZ regulates virulence in Pseudomonas aeruginosa by modulating RsmA binding and gene expression.

Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis

The paper investigates the functional hierarchy of Rab27 effectors in insulin secretion by comparing exocytic phenotypes in beta cells lacking different combinations of effectors.

Development of Equine Polyclonal Antibodies as a Broad-Spectrum Therapy Against SARS-CoV-2 Variants

This paper develops equine polyclonal antibodies that broadly neutralize major SARS-CoV-2 variants, showing high efficacy in vitro and ex vivo with low cost and potential for large-scale production.

Scale Bar of Aging Trajectories for Screening Personal Rejuvenation Treatments

This study develops an aging clock based on blood transcriptome data to assess aging rates and evaluate rejuvenation treatments like NMN and Metformin.

An enzyme-based system for the extraction of small extracellular vesicles from plants

This study develops an enzyme-based method to extract plant extracellular vesicles, showing higher yield and therapeutic potential compared to traditional methods.

Age-related epithelial defects limit thymic function and regeneration

The paper identifies age-related thymic epithelial cell states that impair thymic regeneration and immune function through spatial and single-cell transcriptomics.

Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its pathological conformational conversion

The paper determines the cryo-EM structure of human SOD1 amyloid fibrils, revealing conformational changes associated with ALS pathology.

Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

This study evaluates how well antibodies from mRNA vaccines neutralize SARS-CoV-2 variants, finding that Omicron shows the most escape but booster doses maintain moderate neutralizing activity.

Intracellular glycosyl hydrolase PslG shapes bacterial cell fate, signaling, and the biofilm development of Pseudomonas aeruginosa

This study shows that the intracellular glycosyl hydrolase PslG affects signaling, ePsl structure, cyclic-di-GMP levels, and biofilm formation in Pseudomonas aeruginosa.

Crash landing of Vibrio cholerae by MSHA pili-assisted braking and anchoring in a viscoelastic environment

This study quantifies how Vibrio cholerae lands on surfaces in viscoelastic environments using MSHA pili and flagellum, showing pili act as brakes and anchors during landing.

A Bivalent Chromatin Controls Timing of Expression of Camalexin Biosynthesis Genes in Response to a Pathogen Signal in Arabidopsis

The paper identifies a bivalent chromatin state, called a kairostat, that controls the timing of camalexin biosynthesis gene expression in Arabidopsis in response to pathogen signals.

DEPDC1/ EEF1A1 complex promotes the progression of human osteosarcoma via downregulation of FOXO3a

This study identifies the DEPDC1-EEF1A1-FOXO3a axis as a critical pathway promoting osteosarcoma progression by downregulating FOXO3a, with implications for therapeutic strategies.

Effects of imidacloprid and thiamethoxam at LC30 and LC50 on the life table of soybean aphid Aphis glycines (Hemiptera: Aphididae)

This study examines the effects of imidacloprid and thiamethoxam at LC30 and LC50 concentrations on the life table parameters of soybean aphid, showing significant changes in reproduction and development rates.

Plant Metabolic Network: A multi-species resource of plant metabolic information

The paper updates the Plant Metabolic Network (PMN) with 126 genomes and tools for analyzing metabolism across species, revealing distinct metabolic groups and demonstrating applications in drought tolerance and cell-type specific metabolism.

Familial prion disease-related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM

The paper reports the cryo-EM structure of an amyloid fibril formed by the E196K mutation in human PrP, revealing a distinct conformation compared to wild-type PrP fibrils.

Interdependent Iron and Phosphorus Availability Controls Photosynthesis Through Retrograde Signaling

The paper shows that iron and phosphorus deficiency interact to control photosynthesis through retrograde signaling involving ascorbate transport and transcription factors.

Genomic signature of shifts in selection and alkaline adaptation in highland fish

This study compares 15 fish species to identify genomic signatures of alkaline adaptation in both highland and lowland fish, finding consistent patterns of accelerated evolution and positive selection in shared genes.

Engineered Trimeric ACE2 Binds and Locks "Three-up" Spike Protein to Potently Inhibit SARS-CoVs and Mutants

This study engineers a trimeric ACE2 protein that binds the spike protein with high affinity, inhibiting SARS-CoVs and mutants by locking the spike in a 'three-up' conformation.

The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure

This study reveals that the nuclear localization sequence of hnRNPA1 forms the core of amyloid fibrils and interacts with Kap{beta}2 to stabilize them, linking nucleo-cytoplasmic transport to neurodegeneration.

Parkinson's disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM

The paper determines the cryo-EM structure of phosphorylated α-synuclein fibrils at Tyr39, revealing structural changes linked to Parkinson's disease pathology.

Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin

This paper identifies and characterizes a novel coronavirus (nCoV-2019) causing a human pneumonia outbreak, showing its close genetic relationship to bat coronaviruses and its use of the ACE2 receptor for cell entry.

Acetylation is required for NLRP3 self-aggregation and full activation of the inflammasome

This study identifies acetylation as essential for NLRP3 inflammasome activation, showing that KAT5-mediated acetylation promotes NLRP3 aggregation and inflammasome assembly.

Parkinson's disease associated mutation E46K of α-synuclein triggers the formation of a novel fibril structure

This study determines the cryo-EM structure of a novel α-synuclein fibril formed by the E46K mutation, showing structural changes and altered stability compared to wild-type fibrils.

Phenotypic differences in reversible attachment behavior reveal distinct P. aeruginosa surface colonization strategies

The paper examines reversible attachment behavior in P. aeruginosa strains PAO1 and PA14, revealing distinct surface colonization strategies through single-cell tracking and stochastic modeling.