B. Ho

Cryo-EM Structure of the R388 plasmid conjugative pilus reveals a helical polymer characterised by an unusual pilin/phospholipid binary complex

The paper presents the cryo-EM structure of the R388 plasmid conjugative pilus, revealing a unique pilin/phospholipid complex and structural differences from other conjugative pili.

Measurement of Cervical Neuronal Activity during Stress Challenge Using Novel Flexible Adhesive Surface Electrodes

This paper introduces a novel flexible adhesive electrode array for non-invasive cervical nerve activity monitoring and demonstrates its use in detecting stress-induced neuronal changes.

Extended DNA binding interface beyond the canonical SAP domain contributes to SDE2 function at DNA replication forks

This study identifies a conserved DNA binding motif in SDE2 that extends beyond the canonical SAP domain, enhancing ssDNA binding and replication fork stability.

Gut metabolites are more predictive of disease- and cohoused- states than gut bacterial features in a mouse model of polycystic ovary syndrome

This study shows gut metabolites, especially bile acids, better predict PCOS-like disease and cohousing effects than gut bacteria in a mouse model.

Role of ERK activation in H. pylori-induced disruption of cell-cell tight junctions

This study investigates how H. pylori disrupts cell-cell tight junctions by activating the ERK pathway, showing that inhibiting ERK reduces claudin-4 delocalization and preserves barrier function.

Exposure to a Healthy Gut Microbiome Protects Against Reproductive and Metabolic Dysregulation in a PCOS Mouse Model

This study shows that co-housing PCOS mice with healthy mice improves reproductive and metabolic PCOS symptoms, suggesting gut microbiome manipulation could be a treatment.