Author

M. Seeliger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

P. Tiwary· 2 shared A. Khan· 1 shared A. W. Paton· 1 shared A. Weinheimer· 1 shared B. Ho· 1 shared D. De Sutter· 1 shared D. Wang· 1 shared E. Cloots· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiophysics

P. Tiwary

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Author profile →

4 papers

Recent·Most cited

Calculating Protein-Ligand Residence Times Through State Predictive Information Bottleneck based Enhanced Sampling

S. Lee, D. Wang, M. Seeliger, P. Tiwary

This paper introduces a method to calculate protein-ligand residence times across wide timescales using deep learning and enhanced sampling.

bioRxiv · Apr 16, 2024 · PreprintBiophysics

Extended DNA binding interface beyond the canonical SAP domain contributes to SDE2 function at DNA replication forks

A. Weinheimer, Y. Paung, J. Rageul, A. Khan, B. Ho, M. Tong, S. Alphonse, M. Seeliger, H. Kim

This study identifies a conserved DNA binding motif in SDE2 that extends beyond the canonical SAP domain, enhancing ssDNA binding and replication fork stability.

bioRxiv · May 9, 2022 · PreprintBiochemistry

Protein flexibility and dissociation pathway differentiation can explain onset of resistance mutations in kinases

M. Shekhar, Z. Smith, M. Seeliger, P. Tiwary

This paper uses molecular dynamics simulations to explain how a single point mutation in Abl kinase leads to different dissociation pathways and reduced drug residence time for Imatinib.

bioRxiv · Jul 2, 2021Biochemistry

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

M. J. Grey, E. Cloots, M. S. Simpson, N. LeDuc, Y. Serebrenik, H. De Luca, D. De Sutter, P. Luong, J. R. Thiagarajah, A. W. Paton, J. C. Paton, M. Seeliger, S. Eyckerman, S. Janssens, W. I. Lencer

This study shows IRE1β suppresses IRE1α signaling during ER stress by blocking its activation and disrupting a feedback loop that regulates IRE1 expression.

bioRxiv · Mar 23, 2019Cell Biology