M. Tong

Marker-specific pixel attribution for single-cell protein quantification with PixAQ

PixAQ improves single-cell protein quantification in imaging mass cytometry by assigning pixel signals to specific markers using spatial and intensity models.

Rice OsPLATZ3 controls ROS homeostasis by inhibiting ROS-Scavenging Activity during Tapetum Degeneration

This study identifies OsPLATZ3 as a regulator of ROS homeostasis during tapetum degeneration in rice, showing its role in suppressing ROS scavenging and causing male sterility.

DomainFit: Identification of Protein Domains in cryo-EM maps at Intermediate Resolution using AlphaFold2-predicted Models

DomainFit identifies protein domains in low-resolution cryo-EM maps using AlphaFold2 models, revealing new proteins in cellular complexes.

TLR8-Activating miR-146a-3p is an Intermediate Signal Contributing to Fetal Membrane Inflammation in Response to Bacterial LPS

This study identifies miR-146a-3p as a TLR8-activating microRNA that contributes to fetal membrane inflammation and preterm birth in response to bacterial LPS.

Molecular architecture of the ciliary tip revealed by cryo-electron tomography

The paper uses cryo-electron tomography to reveal the molecular architecture of the ciliary tip in Tetrahymena thermophila, showing cross-linked microtubules and structural features of the central pair.

Cellular, Molecular, and Enzymatic Signatures ofThrombi are Vascular Bed-Dependent

This study compares cellular and enzymatic features of arterial and venous thrombi from different vascular beds, finding distinct molecular profiles and enzyme activities linked to vascular remodeling.

Extended DNA binding interface beyond the canonical SAP domain contributes to SDE2 function at DNA replication forks

This study identifies a conserved DNA binding motif in SDE2 that extends beyond the canonical SAP domain, enhancing ssDNA binding and replication fork stability.

New intranasal and injectable gene therapy for healthy life extension

This paper demonstrates that intranasal and injectable CMV-based gene therapy can extend lifespan and improve health in mice by overexpressing TERT and FST.

New multiscale characterisation methodology for effective determination of isolation-structure-function relationship of extracellular vesicles.

This paper introduces a multiscale characterization method for extracellular vesicles, showing that isolation methods affect their composition and functional effects.

From bud formation to flowering: transcriptomic state defines the cherry developmental phases of sweet cherry bud dormancy

This study identifies transcriptomic changes across sweet cherry bud dormancy stages and develops a model to predict dormancy phases using gene expression data.