B. Joshi

nERdy: network analysis of endoplasmic reticulum dynamics

nERdy and nERdy+ accurately extract and represent ER network dynamics, revealing roles of Atlastin and Reticulon 4 in tubular matrix formation.

RGS2 is an innate immune checkpoint for TLR4 and Gαq-mediated IFNγ generation and lung injury

This study shows RGS2 limits IFNγ production in alveolar macrophages by inhibiting TLR4-Gαq signaling, reducing lung injury in mice and correlating with ARDS patient data.

Basal Gp78-dependent mitophagy promotes mitochondrial health and limits mitochondrial ROS production

This study shows that basal Gp78-dependent mitophagy maintains mitochondrial health by removing low-potential mitochondria, thereby reducing ROS production.

Computer-Vision Stabilized Intravital Imaging Reveals Lung Capillary Neutrophil Dynamics Crucial for Lung Host-Defense Function

This study uses CASTii to analyze lung capillary neutrophil dynamics, revealing their role in host defense and response to infection.

Gp78 E3 ubiquitin ligase mediates both basal and damage-induced mitophagy

This study identifies Gp78 as an E3 ubiquitin ligase that mediates both basal and damage-induced mitophagy through distinct mechanisms involving mitochondrial homeostasis and PINK1.