MicrobiologybioRxiv
SARS-CoV-2 Uses Nonstructural Protein 16 to Evade Restriction by IFIT1 and IFIT3
C. Schindewolf, K. Lokugamage, M. Vu…·V. D. Menachery
This paper shows that SARS-CoV-2's NSP16 protein helps evade immune detection by methylating viral mRNA, and disrupting this function reduces viral replication and disease in hamsters.
DOI 10.1128/jvi.01532-22